Deng RiHui, Liu LiYan, Xie WeiKe, Lu Weiguo, Liu Zhihui, Wang Yang
Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Shanghai Xinchao Medical Laboratory, Shanghai, People's Republic of China.
Infect Drug Resist. 2023 Aug 3;16:5033-5038. doi: 10.2147/IDR.S418482. eCollection 2023.
() infection is a high-risk factor for the occurrence of gastric cancer. The quadruple therapy has been widely used as the first-line treatment for in China. However, the increasing resistance rate to antibiotics has become a major challenge in the treatment of . Therefore, there is an urgent need for rapid and cost-effective detection of antibiotic resistance to different antibiotics. To evaluate the prevalence of antibiotic resistance in Guangzhou and the diagnostic performance of DOB value of 13C UBT in predicting antibiotic resistance.
In this retrospective study, we collected data from 193 culture-positive patients in Guangzhou on their DOB values and resistance to antibiotics. We analyzed the antibiotic resistance rate of commonly used antibiotics in quadruple therapy, and the diagnostic efficacy of DOB value was evaluated.
The resistance rates of clarithromycin (CLA) and levofloxacin (LEV) were 46.1% and 44.0%, respectively. In the age group under 40, the resistance rate of LEV was lower than that of CLA. However, the diagnostic efficacy of DOB value was found to be low and it could not serve as an independent indicator for diagnosing resistance to CLA and LEV.
The high resistance rates of CLA and LEV in patients in Guangzhou indicate the urgent need for effective detection methods. The DOB value is not a direct indicator of antibiotic resistance to CLA and LEV. Therefore, it is important to use a combination of diagnostic methods to accurately assess antibiotic resistance in infection.
（）感染是胃癌发生的高危因素。四联疗法在中国已被广泛用作（）的一线治疗方法。然而，抗生素耐药率的不断上升已成为（）治疗中的一项重大挑战。因此，迫切需要快速且经济高效地检测对不同抗生素的耐药性。评估广州地区（）抗生素耐药性的流行情况以及13C尿素呼气试验（UBT）的DOB值在预测抗生素耐药性方面的诊断性能。
在这项回顾性研究中，我们收集了广州193例（）培养阳性患者的DOB值和抗生素耐药数据。我们分析了四联疗法中常用抗生素的耐药率，并评估了DOB值的诊断效能。
克拉霉素（CLA）和左氧氟沙星（LEV）的耐药率分别为46.1%和44.0%。在40岁以下年龄组中，LEV的耐药率低于CLA。然而，发现DOB值的诊断效能较低，它不能作为诊断CLA和LEV耐药性的独立指标。
广州地区（）患者中CLA和LEV的高耐药率表明迫切需要有效的检测方法。DOB值不是CLA和LEV抗生素耐药性的直接指标。因此，采用多种诊断方法相结合来准确评估（）感染中的抗生素耐药性很重要。
