升级后的D22 SEC-SANS装置，专为生物学界设计。

Upgraded D22 SEC-SANS setup dedicated to the biology community.

作者信息

Martel Anne, Cocho Cristina, Caporaletti Francesca, Jacques Mark, El Aazzouzi Abdelali, Lapeyre Franck, Porcar Lionel

机构信息

Institut Laue-Langevin, 71 avenue de Martyrs, Grenoble 38042, France.

Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, Sweden.

出版信息

J Appl Crystallogr. 2023 Jun 12;56(Pt 4):994-1001. doi: 10.1107/S1600576723004119. eCollection 2023 Aug 1.

Described here is the current status of the upgraded size-exclusion chromatography (SEC) system implemented with the D22 small-angle neutron scattering (SANS) instrument at the Institut Laue-Langevin. Since its initial proof of principle in 2016, this SEC-SANS arrangement has been continuously requested by the user community, leading to the design of an upgraded version. A detailed description of the setup and its control is provided, and a few examples of protein structural investigations are presented, which will highlight the various possibilities and limitations of the setup to optimize experimental success.