Aliev T A, Nasibov A I
Probl Endokrinol (Mosk). 1986 May-Jun;32(3):7-10.
A study was made of the time course of the indices of the cellular and humoral immunity in 202 patients with diffuse toxic goiter (grave and moderately grave forms of the disease) aged 17 to 50 with a period of disease from 6 mos to 25 yrs and in 30 healthy persons of the same age. A decrease in the content of T-lymphocytes in the blood in percentage and absolute quantities, an increase in the content of O-lymphocytes and serum IgM and IgG indicated profound disorders in the immunological status of patients with diffuse toxic goiter. It was mostly observed in the patients with a period of disease up to 10 yrs.
对202例年龄在17至50岁、病程为6个月至25年的弥漫性毒性甲状腺肿（疾病的重度和中度重度形式）患者以及30例同龄健康人的细胞免疫和体液免疫指标的时间进程进行了研究。血液中T淋巴细胞含量在百分比和绝对数量上均下降，O淋巴细胞、血清IgM和IgG含量增加，这表明弥漫性毒性甲状腺肿患者的免疫状态存在严重紊乱。这种情况在病程长达10年的患者中最为常见。
