Department of Surgery, PGIMER, Chandigarh, India.
Department of Anaesthesia and Critical Care, PGIMER, Chandigarh, India.
Indian J Pharmacol. 2023 May-Jun;55(3):174-178. doi: 10.4103/ijp.ijp_827_22.
This study evaluated the efficacy of intraperitoneal magnesium sulfate (MgSO) in preventing postoperative pain after elective laparoscopic cholecystectomy (LC). It is a prospective, double-blinded, placebo-controlled, randomized trial which included 64 patients who underwent LC. Patients were equally randomized into Groups A and B. MgSO and normal saline were instilled in subdiaphragmatic space in Groups A and B, respectively, after creating pneumoperitoneum and before starting dissection. The Visual analogue Scale (VAS) was used to determine postoperative pain. Patients who received intraperitoneal MgSO had lower average VAS scores for the first 6 h postoperatively, and also, the time for the requirement of first analgesic was longer (3.6 ± 0.4 vs. 2.3 ± 1.0 h). The incidence of vomiting and the requirement for rescue antiemetic was also lower in Group A. Intraperitoneal instillation of MgSO reduces postoperative pain and vomiting following elective LC without incurring additional side effects.
本研究评估了腹腔内硫酸镁（MgSO）在预防择期腹腔镜胆囊切除术（LC）后术后疼痛的疗效。这是一项前瞻性、双盲、安慰剂对照、随机临床试验，纳入了 64 例接受 LC 的患者。患者被平均分为 A 组和 B 组。在建立气腹和开始解剖之前，分别在 A 组和 B 组的膈肌下空间注入 MgSO 和生理盐水。术后疼痛采用视觉模拟评分（VAS）进行评估。接受腹腔内 MgSO 的患者术后前 6 小时的平均 VAS 评分较低，并且需要首次镇痛的时间也更长（3.6 ± 0.4 vs. 2.3 ± 1.0 h）。A 组的呕吐发生率和需要使用止吐药的情况也较低。腹腔内灌注 MgSO 可减轻择期 LC 术后的疼痛和呕吐，且无额外的副作用。
