Khmel'nitskiĭ O K, Morozov V G, Khavinson V Kh
Arkh Patol. 1986;48(5):49-53.
The effect of levamisole as well as thymic (thymalin and bone marrow (hemalin) immunomodulators on the immunogenesis organs in practically healthy animals were studied. The comparison of multiple parameters of morphological changes developing in the immunocompetent organs under the influence of immunomodulators was performed by means of so called "similarity ratio". Morphological changes in the central organs of immunogenesis were more severe after the administration of hemalin than after levamisole. The influence of immunomodulators on the peripheral organs of immunogenesis were more uniform. The results obtained in the experiments on healthy animals may serve the basis for a further morphological analysis of the immunomodulators effects under the conditions of the immune homeostasis disturbance.
研究了左旋咪唑以及胸腺（胸腺素）和骨髓（血生素）免疫调节剂对实际健康动物免疫发生器官的影响。借助所谓的“相似比”，对免疫调节剂作用下免疫活性器官中发生的形态学变化的多个参数进行了比较。血生素给药后免疫发生中心器官的形态学变化比左旋咪唑给药后更严重。免疫调节剂对免疫发生外周器官的影响更一致。在健康动物实验中获得的结果可为在免疫稳态紊乱条件下对免疫调节剂作用进行进一步形态学分析提供依据。
