Department of Psychiatry, Psychotherapy, Psychosomatics and Medical Psychology, University Hospital for Psychiatry I, Innsbruck, Austria.
Int Clin Psychopharmacol. 2024 Jan 1;39(1):36-41. doi: 10.1097/YIC.0000000000000495. Epub 2023 Aug 9.
Patients suffering from schizophrenia are at high risk for admission and treatment in locked units. This study investigated gender differences in the pharmacological emergency treatment of schizophrenia patients over a 21-year observation period. The current retrospective study was conducted at the Division of Psychiatry I of the Medical University Innsbruck. All adult patients (n = 845; 425 female) suffering from schizophrenia who were admitted involuntarily to one of the acute psychiatric units in the years 1997, 2002, 2007, 2012 and 2017 were included in the study. In the years mentioned above, 590 schizophrenia patients (297 men, 293 women) admitted to a locked unit received pharmacological emergency treatment. With the exception of clozapine which was more frequently administered to men no significant differences between men and women were found in terms of the choice, dosage, and type of application of medication (antipsychotics and benzodiazepines). Since most treatment guidelines for schizophrenia do not consider gender differences at all, it is not surprising that acute treatment is almost the same for men and women. However, in times when individualized therapies gain more and more importance, the consideration of sex differences should be part of new treatment concepts.
患有精神分裂症的患者住院和接受封闭病房治疗的风险很高。本研究调查了 21 年观察期间精神分裂症患者药物急救治疗的性别差异。本回顾性研究在因斯布鲁克医科大学精神病学 I 科进行。所有成年患者（n=845；425 名女性）均患有精神分裂症，他们在 1997 年、2002 年、2007 年、2012 年和 2017 年期间被非自愿收治到一个急性精神病病房。在上述年份中，590 名（297 名男性，293 名女性）被收治到封闭病房的精神分裂症患者接受了药物急救治疗。除了氯氮平更常被用于男性外，在药物选择、剂量和应用类型（抗精神病药和苯二氮䓬类药物）方面，男性和女性之间没有发现显著差异。由于大多数精神分裂症治疗指南根本不考虑性别差异，因此急性治疗对男性和女性几乎相同也就不足为奇了。然而，在个体化治疗越来越重要的时代，考虑性别差异应该成为新治疗概念的一部分。
