Biomedical and Metabolic Imaging Branch (BMIB), National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), 10 Center Drive, 1C334, Bethesda, MD, 20892, USA.
Internal Medicine, Endocrinology, and Genetics, Division of Endocrinology, University of British Columbia, Vancouver, BC, Canada.
J Cardiovasc Transl Res. 2024 Apr;17(2):298-307. doi: 10.1007/s12265-023-10422-5. Epub 2023 Aug 9.
Coronary artery disease (CAD) risk and plaque scores are often subjective and biased, particularly in mid-age asymptomatic women, whose CAD risk assessment has been historically underestimated. In this study, a new automatic ascending aorta time-to-peak-distention (TPD) analysis was developed for fast screening and as an independent surrogate for subclinical atherosclerosis in asymptomatic women. CCTA was obtained in 50 asymptomatic adults. Plaque burden segment involvement score (SIS) and automatic TPD were obtained from all subjects. Logistic regression analyses were performed to investigate the association between CAD risk scores and TPD with severe coronary plaque burden (SIS>5). TPD, individually, was found to be a significant predictor of SIS>5. Additionally, sex was a significant effect modifier of TPD, with a stronger statistically significant association with women. Four-dimensional aortic time-to-peak distention could supplement conventional CCTA analysis and offer a quick objective screening tool for plaque burden severity and CAD risk stratification, especially in women.
冠状动脉疾病 (CAD) 风险和斑块评分往往具有主观性和偏差性，尤其是在中年无症状女性中，其 CAD 风险评估历史上一直被低估。在这项研究中，开发了一种新的自动升主动脉达峰时间扩张 (TPD) 分析方法，用于快速筛查和作为无症状女性亚临床动脉粥样硬化的独立替代指标。对 50 名无症状成年人进行 CCTA 检查。从所有受试者中获得斑块负荷节段受累评分 (SIS) 和自动 TPD。进行逻辑回归分析以研究 CAD 风险评分与 TPD 与严重冠状动脉斑块负荷 (SIS>5) 之间的关系。TPD 是 SIS>5 的重要预测因子。此外，性别是 TPD 的重要效应修饰因子，与女性的关联具有更强的统计学意义。四维主动脉达峰时间扩张可以补充传统的 CCTA 分析，并提供一种快速客观的斑块负荷严重程度和 CAD 风险分层筛查工具，特别是在女性中。
