Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Division of Maternal-Fetal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Environ Health Perspect. 2023 Aug;131(8):87005. doi: 10.1289/EHP11909. Epub 2023 Aug 9.
Exposures to ambient air pollution during pregnancy have been linked to adverse pregnancy outcomes such as preeclampsia and fetal growth restriction. Although evidence has shown that women with preeclampsia have higher ratio of soluble fms-like tyrosine kinase 1 to placental growth factor (sFlt-1/PlGF ratio), the potential impact of air pollution on markers of placental growth and function has not been well studied.
We aimed to examine longitudinal associations between ambient air pollution exposure and angiogenic factors among pregnant women in LIFECODES, a prospective birth cohort and biorepository in Massachusetts in the United States.
PlGF and sFlt-1 were measured among pregnant women using plasma samples collected around 10, 18, 26, and 35 wk' gestation. Women's exposures to ozone (), fine particulate matter with aerodynamic diameter (), and nitrogen dioxide () within 1, 2, 4, and 8 wk prior to each plasma sample collection were estimated based on geocoded residential addresses, and mixed effect linear regression models were fitted to assess their associations with sFlt-1/PlGF ratio, sFlt-1 (ng/mL), and PlGF (pg/mL). Percent changes in outcomes associated with each interquartile range increase in exposures were reported, along with their 95% confidence intervals.
A total of 1,066 pregnant women were included. In the multipollutant models, significant associations were observed for increased sFlt-1/PlGF ratio ( 3-8 wk' gestation, : 35-39 wk' gestation), elevated sFlt-1 (: 26-34 wk' gestation, : 3-8 wk' gestation), decreased sFlt-1 (: 4-8 wk' gestation), and decreased PlGF (: 34-39 wk' gestation) after adjusting for sociodemographic status, smoking, drinking, body mass index, parity, history of chronic hypertension, and conception time.
Exposures to during early pregnancy and exposures to and during late pregnancy were associated with increased sFlt-1/PlGF ratio, elevated sFlt-1 and with decreased PlGF, which may be a potential mechanism underlying ambient air pollution's impacts on adverse pregnancy and birth outcomes. https://doi.org/10.1289/EHP11909.
孕期暴露于环境空气污染与子痫前期和胎儿生长受限等不良妊娠结局有关。尽管有证据表明，子痫前期患者可溶性 fms 样酪氨酸激酶 1 与胎盘生长因子（sFlt-1/PlGF 比值）的比值更高，但空气污染对胎盘生长和功能标志物的潜在影响尚未得到充分研究。
我们旨在通过在美国马萨诸塞州的 LIFECODES 前瞻性出生队列和生物库中，检测孕妇在孕期中暴露于环境空气污染与血管生成因子之间的纵向关联。
在妊娠 10、18、26 和 35 周左右采集孕妇的血浆样本，检测 PlGF 和 sFlt-1。根据孕妇居住地址的地理编码，估算她们在每次采集血浆样本前 1、2、4 和 8 周内接触臭氧（）、细颗粒物（空气动力学直径（））和二氧化氮（）的情况，并使用混合效应线性回归模型评估它们与 sFlt-1/PlGF 比值、sFlt-1（ng/mL）和 PlGF（pg/mL）之间的关联。报告与暴露增加每一个四分位距相关的结果变化百分比，以及它们的 95%置信区间。
共纳入 1066 名孕妇。在多污染物模型中，调整社会人口统计学特征、吸烟、饮酒、体重指数、产次、慢性高血压病史和受孕时间后，在妊娠早期接触增加的 sFlt-1/PlGF 比值（3-8 周）、升高的 sFlt-1（26-34 周）、降低的 sFlt-1（4-8 周）和降低的 PlGF（34-39 周）与接触 相关。
在妊娠早期接触和在妊娠晚期接触 和 与增加的 sFlt-1/PlGF 比值、升高的 sFlt-1 和降低的 PlGF 相关，这可能是环境空气污染对不良妊娠和出生结局影响的潜在机制。https://doi.org/10.1289/EHP11909.
