Snoeckx L H, Schrijen J J, van Bilsen M, Lammers W J, van der Nagel T, van der Vusse G J, Reneman R S
Comput Biol Med. 1986;16(4):301-9. doi: 10.1016/0010-4825(86)90014-4.
This study describes the application of an Apple IIe microcomputer in combination with a pre-processor in the on-line calculation of haemodynamic variables of the isolated working rat heart and of relative rapid changes in these variables, induced by variations in left atrial filling pressure (preload) and end-diastolic aortic pressure (afterload). Variables such as heart rate, systolic and diastolic left ventricular pressure, the maximal positive and negative first derivative of the left ventricular pressure, systolic and diastolic aortic pressure and aortic flow were continuously calculated and printed at minimal intervals of 6 s. A newly designed procedure to detect the activation of the electrogram, which was necessary to start the detection of a new cardiac cycle, is described.
本研究描述了苹果IIe微型计算机与预处理机相结合，用于在线计算离体工作大鼠心脏的血流动力学变量以及由左心房充盈压（前负荷）和舒张末期主动脉压（后负荷）变化引起的这些变量的相对快速变化。诸如心率、左心室收缩压和舒张压、左心室压力的最大正负一阶导数、主动脉收缩压和舒张压以及主动脉血流量等变量以最少6秒的间隔持续计算并打印。本文还描述了一种新设计的检测心电图激活的程序，这是开始检测新心动周期所必需的。
