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人类血型糖蛋白A和B由单独的单拷贝基因编码，这些基因受促肿瘤佛波酯的协同调控。

Human glycophorin A and B are encoded by separate, single copy genes coordinately regulated by a tumor-promoting phorbol ester.

作者信息

Siebert P D, Fukuda M

出版信息

J Biol Chem. 1986 Sep 25;261(27):12433-6.

PMID:3755722
Abstract

Human glycophorin A belongs to a family of structurally related cell surface glycoproteins which are expressed in erythroid cells. We have recently isolated several human glycophorin A-specific cDNA clones and have determined their nucleotide sequence (Siebert, P. D., and Fukuda, M. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 1665-1669). In this report by using cDNA and exact sequence synthetic oligodeoxyribonucleotides as hybridization probes, we provide evidence that human glycophorin A and B are encoded by separate and distinct genes present as single copies in the human genome. Furthermore, we show that the expression of the glycophorin A and B genes are coordinately regulated by tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate.

摘要

人血型糖蛋白A属于一类结构相关的细胞表面糖蛋白家族，在红细胞中表达。我们最近分离出了几个特异性针对人血型糖蛋白A的cDNA克隆，并确定了它们的核苷酸序列（西伯特，P.D.，和福田，M.（1986年）《美国国家科学院院刊》83卷，1665 - 1669页）。在本报告中，通过使用cDNA和精确序列的合成寡脱氧核糖核苷酸作为杂交探针，我们提供证据表明人血型糖蛋白A和B由人基因组中以单拷贝形式存在的单独且不同的基因编码。此外，我们表明血型糖蛋白A和B基因的表达受到促肿瘤佛波酯12 - O - 十四酰佛波醇 - 13 - 乙酸酯的协同调控。

相似文献

1
Human glycophorin A and B are encoded by separate, single copy genes coordinately regulated by a tumor-promoting phorbol ester.人类血型糖蛋白A和B由单独的单拷贝基因编码，这些基因受促肿瘤佛波酯的协同调控。
J Biol Chem. 1986 Sep 25;261(27):12433-6.
2
Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction.通过利用聚合酶链反应分离基因组克隆和互补DNA克隆来鉴定一种新型人类血型糖蛋白——血型糖蛋白E。
J Biol Chem. 1990 Jan 15;265(2):1102-10.
3
Regulation of glycophorin gene expression by a tumor-promoting phorbol ester in human leukemic K562 cells.
J Biol Chem. 1985 Jan 10;260(1):640-5.
4
Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A.人血型糖蛋白B cDNA的分子克隆：核苷酸序列及其与血型糖蛋白A的基因组关系
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6735-9. doi: 10.1073/pnas.84.19.6735.
5
Identification of the crossing-over point of a hybrid gene encoding human glycophorin variant Sta. Similarity to the crossing-over point in haptoglobin-related genes.编码人血型糖蛋白变体Sta的杂交基因交叉点的鉴定。与触珠蛋白相关基因中交叉点的相似性。
J Biol Chem. 1990 Jun 5;265(16):9259-63.
6
Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure.用合成寡核苷酸方法分离和鉴定人血型糖蛋白A cDNA克隆：核苷酸序列和mRNA结构
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1665-9. doi: 10.1073/pnas.83.6.1665.
7
Glycophorin B and glycophorin E genes arose from the glycophorin A ancestral gene via two duplications during primate evolution.血型糖蛋白B和血型糖蛋白E基因是在灵长类动物进化过程中通过两次复制从血型糖蛋白A祖先基因产生的。
J Biol Chem. 1993 Jan 25;268(3):2260-7.
8
Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C.人红细胞血型糖蛋白C的cDNA克隆分离及完整氨基酸序列
J Biol Chem. 1986 Jan 5;261(1):229-33.
9
Positive and negative regulation of specific gene expression by the tumor promoter TPA in human erythroleukemic K562 cells.肿瘤启动子佛波酯（TPA）对人红白血病K562细胞中特定基因表达的正负调控
Prog Clin Biol Res. 1985;191:233-48.
10
Genomic organization of glycophorin A gene family revealed by yeast artificial chromosomes containing human genomic DNA.含人类基因组DNA的酵母人工染色体揭示的血型糖蛋白A基因家族的基因组组织
J Biol Chem. 1994 Apr 29;269(17):13013-20.

引用本文的文献

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Erythrocyte glycophorins as receptors for Plasmodium merozoites.红细胞糖苷脂作为疟原虫裂殖子的受体。
Parasit Vectors. 2019 Jun 24;12(1):317. doi: 10.1186/s13071-019-3575-8.
2
Human erythrocyte membrane sialoglycoprotein beta. The cDNA sequence suggests the absence of a cleaved N-terminal signal sequence.人红细胞膜唾液酸糖蛋白β。cDNA序列表明不存在可裂解的N端信号序列。
Biochem J. 1987 Apr 1;243(1):277-80. doi: 10.1042/bj2430277.
3
Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A.
人血型糖蛋白B cDNA的分子克隆：核苷酸序列及其与血型糖蛋白A的基因组关系
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6735-9. doi: 10.1073/pnas.84.19.6735.
4
Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta.人红细胞膜唾液酸糖蛋白α和δ的cDNA克隆的分离
Biochem J. 1988 Sep 15;254(3):743-50. doi: 10.1042/bj2540743.
5
Regulation of erythroid cell-specific gene expression during erythropoiesis.红细胞生成过程中红细胞特异性基因表达的调控。
Br J Cancer Suppl. 1988 Dec;9:46-51.
6
Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences.血型糖蛋白A和B基因的结构组织：血型糖蛋白B基因通过Alu重复序列处的同源重组进化而来。
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4619-23. doi: 10.1073/pnas.86.12.4619.
7
Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells.3型蛋白激酶C定位于佛波酯处理的NIH 3T3细胞的核膜。
J Cell Biol. 1989 Aug;109(2):685-95. doi: 10.1083/jcb.109.2.685.
8
Studies on human red-cell membrane glycophorin A and glycophorin B genes in glycophorin-deficient individuals.糖蛋白缺乏个体的人类红细胞膜血型糖蛋白A和血型糖蛋白B基因研究。
Biochem J. 1989 Nov 1;263(3):993-6. doi: 10.1042/bj2630993.
9
The M13 repeat probe detects RFLPs between two strains of the protozoan malaria parasite Plasmodium falciparum.M13重复探针可检测恶性疟原虫这一原生动物疟原虫的两个菌株之间的限制性片段长度多态性。
Nucleic Acids Res. 1989 May 11;17(9):3610. doi: 10.1093/nar/17.9.3610.
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Chromosomal mapping of the ubiquitin gene family in Saccharomyces cerevisiae by pulsed field gel electrophoresis.利用脉冲场凝胶电泳对酿酒酵母泛素基因家族进行染色体定位
Nucleic Acids Res. 1989 May 11;17(9):3611-2. doi: 10.1093/nar/17.9.3611.