Zhang Le, Xu Jinjin, Li Muxuan, Chen Xiujuan
Center for Reproductive Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China.
Department of Imaging Medicine, The People's Hospital of the Inner Mongolia Autonomous Region, Hohhot 010017, Inner Mongolia, China.
Cell Signal. 2023 Nov;111:110848. doi: 10.1016/j.cellsig.2023.110848. Epub 2023 Aug 7.
Long noncoding RNAs (lncRNAs), which are among the most well-characterized noncoding RNAs, have attracted much attention due to their regulatory functions and potential therapeutic options in many types of disease. Liquid-liquid phase separation (LLPS), the formation of droplet condensates, is involved in various cellular processes, but the molecular interactions of lncRNAs in LLPS are unclear. In this review, we describe the research development on LLPS, including descriptions of various methods established to identify LLPS, summarize the physiological and pathological functions of LLPS, identify the molecular interactions of lncRNAs in LLPS, and present the potential applications of leveraging LLPS in the clinic. The aim of this review is to update the knowledge on the association between LLPS and lncRNAs, which might provide a new direction for the treatment of LLPS-mediated disease.
长链非编码RNA（lncRNAs）是特征最为明确的非编码RNA之一，因其在多种疾病中的调控功能和潜在治疗选择而备受关注。液-液相分离（LLPS），即液滴凝聚物的形成，参与了各种细胞过程，但lncRNAs在LLPS中的分子相互作用尚不清楚。在这篇综述中，我们描述了LLPS的研究进展，包括对为鉴定LLPS而建立的各种方法的描述，总结了LLPS的生理和病理功能，确定了lncRNAs在LLPS中的分子相互作用，并介绍了在临床中利用LLPS的潜在应用。这篇综述的目的是更新关于LLPS与lncRNAs之间关联的知识，这可能为治疗LLPS介导的疾病提供新方向。
