Department of Medical Biotechnology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical, Torbat Heydariyeh, Iran.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Nov-Dec;15(6):e1920. doi: 10.1002/wnan.1920. Epub 2023 Aug 9.
Nanoemulsions (NEs) are emulsions with particle size of less than around 100 nm. Reviewing the literature, several reports are available on NEs, including preparation, characterization, and applications of them. This review aims to brief challenges that researchers or formulators may encounter when working with NEs. For instance, when selecting NE components and identifying their concentrations, stability and safety of the preparation should be evaluated. When preparing an NE, issues over scale-up of the preparation as well as possible effects of the preparation process on the active ingredient need to be considered. When characterizing the NEs, the two major concerns are accuracy of the method and accessibility of the characterizing instrument. Also a highly efficient NE for clinical use to deliver the active ingredient to the target tissue with maximum safety profile is commonly sought. Throughout the review we also have tried to suggest approaches to overcome the challenges. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.
纳米乳（NE）是粒径小于 100nm 的乳液。查阅文献，有许多关于 NE 的报道，包括它们的制备、表征和应用。本篇综述旨在简述研究人员或制剂开发者在使用 NE 时可能遇到的挑战。例如，在选择 NE 成分并确定其浓度时，应评估制剂的稳定性和安全性。在制备 NE 时，需要考虑制剂放大过程中的问题以及制备过程对活性成分可能产生的影响。在对 NE 进行表征时，主要关注方法的准确性和表征仪器的可及性。此外，还通常需要寻找一种高效的 NE，以最大的安全性将活性成分递送至靶向组织用于临床应用。在整篇综述中，我们还试图提出克服这些挑战的方法。本文属于以下分类：治疗方法和药物发现 > 新兴技术。
