Radiology Department of Iran University of Medical Sciences (IUMS), Tehran, Iran.
Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.
Cancer Rep (Hoboken). 2023 Oct;6(10):e1883. doi: 10.1002/cnr2.1883. Epub 2023 Aug 9.
Chondrosarcomas are an exceedingly rare form of cancer, impacting only a few individuals per million. Among chondrosarcomas, a small fraction belongs to the mesenchymal sub-type. Furthermore, only one-third of mesenchymal chondrosarcomas manifest in extraskeletal locations.
A 38-year-old woman was referred by a midwife after experiencing pain in the right upper quadrant of her right breast for 2 months. The mass had been palpable for 1 week before the initial assessment. According to radiological evaluations, the tumor is outside breast tissue and not connected to the bones. Hence, a biopsy of the mass is done. The biphasic morphology of the tumor during pathological evaluation, in addition to immunohistochemistry testing, confirms the diagnosis of extraskeletal mesenchymal chondrosarcoma (EMCS). Finally, the mass was surgically removed, and 6 months of chemotherapy were administered to the patient.
Given the tumor's rarity and the lack of established guidelines, diagnosing EMCS can be challenging and prone to errors. As such, meticulous sampling, along with precise pathological and imaging investigations, is imperative to accurately establish the diagnosis of these tumors.
软骨肉瘤是一种极其罕见的癌症，每百万人中只有少数几个人会受到影响。在软骨肉瘤中，一小部分属于间充质亚型。此外，只有三分之一的间充质软骨肉瘤出现在骨骼外部位。
一位 38 岁的女性因右乳房右上象限疼痛 2 个月，由助产士转介。肿块在首次评估前 1 周可触及。根据影像学评估，肿瘤位于乳腺组织外，与骨骼无关。因此，对肿块进行了活检。病理评估时肿瘤的双相形态，加上免疫组织化学检测，证实了 extraskeletal 间充质软骨肉瘤（EMCS）的诊断。最后，对肿块进行了手术切除，并对患者进行了 6 个月的化疗。
鉴于肿瘤的罕见性和缺乏既定的指南，诊断 EMCS 可能具有挑战性且容易出错。因此，精细的取样，以及精确的病理和影像学检查，对于准确诊断这些肿瘤至关重要。
