长期饮酒后钙信号转导的改变。

Altered calcium signal transduction after chronic ethanol consumption.

作者信息

Rius R A, Govoni S, Guagno L, Araujo A C, Trabucchi M

出版信息

Alcohol. 1986 Jul-Aug;3(4):233-8. doi: 10.1016/0741-8329(86)90031-5.

Abstract

Calcium and calcium-calmodulin dependent phosphorylation of several protein bands was found altered in synaptosomal membranes prepared from ethanol treated rats. The ethanol induced effect on Ca++ and Ca++-calmodulin phosphorylation presented regional differences. In particular 32P incorporation was lower in the striatum and cerebellum, higher in the hippocampus and unmodified in the cortex. Part of the phosphorylated bands had an apparent molecular weight similar to that of the phosphoproteins involved in neurotransmission. These results extend previous observations indicating that calcium movement control is modified during chronic ethanol consumption and suggest that ethanol may interfere at various steps in the calcium-promoted events.

摘要

在由乙醇处理过的大鼠制备的突触体膜中，发现几种蛋白条带的钙及钙调蛋白依赖性磷酸化发生了改变。乙醇对钙离子及钙调蛋白磷酸化的诱导作用存在区域差异。具体而言，纹状体和小脑中的32P掺入量较低，海马体中的较高，而皮质中的则未改变。部分磷酸化条带的表观分子量与参与神经传递的磷蛋白相似。这些结果扩展了先前的观察结果，表明在长期乙醇摄入期间钙移动控制受到了改变，并提示乙醇可能在钙促进的事件的各个步骤中产生干扰。