Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Patna, Bihar, India.
Department of Pharmacology, University College of Medical Sciences, New Delhi, India.
Recent Adv Food Nutr Agric. 2023;14(3):190-196. doi: 10.2174/2772574X14666230808095649.
The ongoing pandemic of severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2) has caused an immense public health crisis worldwide. Emerging evidence has suggested that inflammatory response plays a critical role in the pathogenesis and prognosis of the disease. As vitamin D can modulate the immune system, this study has been designed to correlate vitamin D with inflammatory and prognostic markers in COVID-19 patients.
The present study is a retrospective study examining the relationship between vitamin D levels and inflammatory markers in the COVID-19 disease. COVID-19 patients who were investigated for vitamin D, ferritin, D-dimer, C-reactive protein (CRP), and procalcitonin (PCT) level were only included. The patients were divided into hypovitaminosis D, and normal vitamin D. Correlation and logistic regression analyses were carried out to identify the strength and association of hypovitaminosis D with inflammatory markers in COVID-19 disease.
The hypovitaminosis D group had significantly higher inflammatory markers compared to the normal vitamin D group. The correlation between hypovitaminosis D and procalcitonin was negative (r = -0.433), with a strong and significant association (p = 0.002). The correlation between hypovitaminosis D, CRP, and ferritin was weak and insignificant. The logistic regression between hypovitaminosis D and procalcitonin established a significant regression equation, leading to a significant linear model.
This study concludes that patients with hypovitaminosis D should be treated with vitamin D therapy to reduce the severity of COVID-19 disease.
严重急性呼吸综合征冠状病毒 2019（SARS-CoV-2）的持续大流行在全球范围内造成了巨大的公共卫生危机。新出现的证据表明，炎症反应在疾病的发病机制和预后中起着关键作用。由于维生素 D 可以调节免疫系统，因此本研究旨在探讨维生素 D 与 COVID-19 患者的炎症和预后标志物之间的相关性。
本研究是一项回顾性研究，旨在研究维生素 D 水平与 COVID-19 疾病中炎症标志物之间的关系。仅纳入了检测维生素 D、铁蛋白、D-二聚体、C 反应蛋白（CRP）和降钙素原（PCT）水平的 COVID-19 患者。将患者分为维生素 D 缺乏症和正常维生素 D 组。进行相关性和逻辑回归分析，以确定维生素 D 缺乏症与 COVID-19 疾病中炎症标志物的强度和关联。
维生素 D 缺乏症组的炎症标志物明显高于正常维生素 D 组。维生素 D 缺乏症与降钙素原呈负相关（r = -0.433），具有很强的显著相关性（p = 0.002）。维生素 D 缺乏症与 CRP 和铁蛋白之间的相关性较弱且无统计学意义。维生素 D 缺乏症与降钙素原之间的逻辑回归建立了一个显著的回归方程，导致一个显著的线性模型。
本研究得出结论，维生素 D 缺乏症患者应接受维生素 D 治疗以减轻 COVID-19 疾病的严重程度。
