丹麦新冠疫情封锁期间老年人肺炎球菌携带率下降
Decreased Pneumococcal Carriage Among Older Adults in Denmark During the COVID-19 Lockdown.
作者信息
Tinggaard Michaela, Slotved Hans-Christian, Petersen Randi Føns, Hovmand Nichlas, Benfield Thomas
机构信息
Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
出版信息
Open Forum Infect Dis. 2023 Jul 20;10(8):ofad365. doi: 10.1093/ofid/ofad365. eCollection 2023 Aug.
BACKGROUND
COVID-19 containment measures reduced the burden of invasive pneumococcal disease. Data on pneumococcal carriage rates among adults during the pandemic are scarce.
METHODS
Naso- and oropharyngeal swabs and questionnaires were collected during January 2019 to December 2021 from adults ≥64 years of age. Carriage was determined by PCR.
RESULTS
A total of 1556 participants provided paired naso- and oropharyngeal swabs. Their median age was 74 years (IQR, 70-79). DNA was detected in 146 (9.4%) oropharyngeal swabs and 34 (2.2%) nasopharyngeal. The carriage rate decreased from 12.9% (95% CI, 10.1%-16.1%, n = 66/511) prelockdown (January 2019-February 2020) to 4.2% (95% CI, 2.0%-7.5%, n = 10/240) during lockdown (March 2020-February 2021) and increased to 12.1% (95% CI, 9.8%-14.7%, n = 87/719) with the reopening of society (March 2021-December 2021; = .0009).
CONCLUSIONS
Pneumococcal carriage prevalence declined significantly during pandemic mitigation measures and rebounded to prepandemic levels as measures were lifted.
背景
COVID-19防控措施减轻了侵袭性肺炎球菌病的负担。关于疫情期间成年人肺炎球菌携带率的数据很少。
方法
在2019年1月至2021年12月期间收集了64岁及以上成年人的鼻咽拭子和口咽拭子以及问卷。通过PCR确定携带情况。
结果
共有1556名参与者提供了配对的鼻咽拭子和口咽拭子。他们的中位年龄为74岁（四分位间距，70-79岁）。在146份（9.4%）口咽拭子和34份（2.2%）鼻咽拭子中检测到DNA。携带率从封锁前（2019年1月至2020年2月）的12.9%（95%CI，10.1%-16.1%，n=66/511）降至封锁期间（2020年3月至2021年2月）的4.2%（95%CI，2.0%-7.5%，n=10/240），随着社会重新开放（2021年3月至2021年12月）又升至12.1%（95%CI，9.8%-14.7%，n=87/719；P=.0009）。
结论
在疫情缓解措施期间，肺炎球菌携带率显著下降，随着措施解除，又反弹至疫情前水平。
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