Oh Jung-Min, Kim Hongtae
Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University Yangsan 50612, Republic of Korea.
Department of Life Science in Dentistry, School of Dentistry, Pusan National University Yangsan 50612, Republic of Korea.
Am J Cancer Res. 2023 Jul 15;13(7):3157-3168. eCollection 2023.
Maintaining and transferring intact genomes from one generation to another plays a pivotal role in all living organisms. DNA damage caused by numerous endogenous and exogenous factors must be adequately repaired, as unrepaired and accumulated DNA mutations can cause severe deleterious effects, such as cell death and cancer. To prevent adverse consequences, cells have established DNA damage response mechanisms that address different forms of DNA damage, including DNA double-strand breaks, mismatches, nucleotide excision, and base excision. Among several sources of exogenous DNA damage, bacterial infections cause inflammation in the host, generating reactive oxygen species (ROS) and causing oxidative DNA damage. Recent studies have revealed the importance of the oral microbiome in inflammation and several systemic host diseases. Dysbiosis of oral bacteria can induce chronic inflammation, which enhances ROS-induced DNA damage, and improperly repaired damage can lead to carcinogenesis. This review describes the various DNA repair pathways that are affected by chronic inflammation and the discovery of the DNA damage response induced by oral bacteria such as and .
将完整的基因组从一代维持并传递到下一代在所有生物中都起着关键作用。由众多内源性和外源性因素导致的DNA损伤必须得到充分修复，因为未修复和积累的DNA突变会造成严重的有害影响，如细胞死亡和癌症。为防止出现不良后果，细胞建立了DNA损伤应答机制，以应对不同形式的DNA损伤，包括DNA双链断裂、错配、核苷酸切除和碱基切除。在多种外源性DNA损伤来源中，细菌感染会在宿主体内引发炎症，产生活性氧（ROS）并造成氧化性DNA损伤。最近的研究揭示了口腔微生物群在炎症和几种全身性宿主疾病中的重要性。口腔细菌的生态失调可诱发慢性炎症，这会加剧ROS诱导的DNA损伤，而修复不当的损伤可能导致癌变。本综述描述了受慢性炎症影响的各种DNA修复途径，以及诸如[具体细菌名称]等口腔细菌诱导的DNA损伤应答的发现。
