Czeizel A, Nagy E
Acta Paediatr Hung. 1986;27(2):145-66.
A case-control epidemiological and family study was organized of 2024 index patients born between 1970 and 1976 affected by isolated cleft lip +/- cleft palate, isolated posterior cleft palate and multiple congenital abnormalities including facial clefting and of their matched control cases. The specific rate of affected parents and sibs was 2.4% and 4.2% in the isolated cleft lip +/- cleft palate sample, while 2.2% and 3.2% in the isolated posterior cleft palate group. The proportion of polygenic liability was about 77 +/- 8% in isolated cleft lip +/- cleft palate cases. Among teratogens, the triggering impact of certain anticonvulsants was confirmed.
针对1970年至1976年出生的2024例患有单纯唇裂±腭裂、单纯腭裂以及包括面部裂在内的多种先天性异常的索引患者及其匹配的对照病例，组织了一项病例对照流行病学和家族研究。在单纯唇裂±腭裂样本中，受影响父母和同胞的特定比率分别为2.4%和4.2%，而在单纯腭裂组中分别为2.2%和3.2%。在单纯唇裂±腭裂病例中，多基因易感性比例约为77±8%。在致畸物中，某些抗惊厥药的触发影响得到了证实。
