Department of Electronics and Communication, M S Ramaiah Institute of Technology, Bangalore, Karnataka 560054, India.
Department of Mathematics, Ramaiah Institute of Technology, MSRIT Nagar, Bangalore 560 054, India.
Crit Rev Biomed Eng. 2023;51(3):1-19. doi: 10.1615/CritRevBiomedEng.2023047066.
Nailfold capillaroscopy is a tool which is non-invasive in nature and can be useful for diagnosis, research, therapeutic study and prognosis. Research shows that specific capillary morphology patterns are identified for diabetic subjects, hypertensive subjects and normal controls. In this study, we have proposed RATHEW approach of classifying these three classes of subjects. RATHEW approach employs a three step process for classifying nailfold images: one, identify six abnormality parameters from the image dataset; two, score these abnormality parameters based on the defined scoring rules; and three, combine them mathematically to segregate them into three classes. This technique can be further enhanced to grade the severity of disease and organ involvement. This can bring in a paradigm shift to the disease detection and therapeutic study mechanism.
甲襞毛细血管显微镜检查是一种非侵入性的工具，可用于诊断、研究、治疗研究和预后。研究表明，为糖尿病患者、高血压患者和正常对照者确定了特定的毛细血管形态模式。在这项研究中，我们提出了 RATHEW 方法来对这三类受试者进行分类。RATHEW 方法采用三步过程对指甲图像进行分类：一、从图像数据集中识别六个异常参数；二、根据定义的评分规则对这些异常参数进行评分；三、通过数学方法将它们结合起来进行分类。该技术可以进一步增强以对疾病的严重程度和器官受累进行分级。这将给疾病检测和治疗研究机制带来范式转变。
