Slater D N, Reilly G
Br J Dermatol. 1986 Sep;115(3):317-27. doi: 10.1111/j.1365-2133.1986.tb05746.x.
The possible clinical value of fine needle aspiration cytology (FNAC) has been assessed prospectively in 60 patients presenting with cutaneous lesions. The cytological diagnosis in each case has been compared with the clinical diagnosis and biopsy result. The principal potential use appears to be the rapid confirmation of the clinical diagnosis of basal cell carcinoma to allow immediate referral for radiotherapy or plastic surgery. FNAC could also prove useful when the clinical diagnosis of malignant melanoma is in doubt and primary diagnostic excision is difficult or disfiguring. Accurate distinction could usually be made between benign and malignant lymphoproliferative conditions, but further classification was difficult. Metastatic malignancy could be diagnosed with ease and other characteristic cytological appearances were seen with naevocellular naevi, pyogenic granuloma and pilar cysts. However, there were limitations in achieving an accurate diagnosis in approximately half the cases, and consequently, FNAC cannot be regarded in general as a substitute for histological diagnosis.
对60例有皮肤病变的患者进行了前瞻性评估，以确定细针穿刺细胞学检查（FNAC）的潜在临床价值。将每例的细胞学诊断与临床诊断及活检结果进行了比较。其主要潜在用途似乎是快速确诊基底细胞癌的临床诊断，以便立即转诊进行放射治疗或整形手术。当恶性黑色素瘤的临床诊断存疑且进行初步诊断性切除困难或会造成毁容时，FNAC也可能有用。通常可以准确区分良性和恶性淋巴增生性疾病，但进一步分类困难。转移性恶性肿瘤很容易诊断，在黑素细胞痣、化脓性肉芽肿和毛囊囊肿中也可见到其他特征性细胞学表现。然而，约半数病例难以做出准确诊断，因此，一般不能将FNAC视为组织学诊断的替代方法。
