Department of Ultrasound, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu Province, China.
Department of Radiotherapy, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu Province, China.
PLoS One. 2023 Aug 10;18(8):e0289598. doi: 10.1371/journal.pone.0289598. eCollection 2023.
The prognostic value of vitamin D receptor (VDR) in a variety of digestive system tumours remains controversial. In view of this, we conducted a meta-analysis. Published studies (as of Mar 30, 2023) assessing the prognostic role of VDR in digestive system tumours were retrieved. Pooled analyses were conducted based on the hazard ratios (HRs) of high VDR expression extracted from the included studies. If heterogeneity was detected, the random-effects model was used; otherwise, the fixed-effects model was used. Subgroup analysis, sensitivity analysis and meta-regression were performed to explore the sources of heterogeneity. Eight studies with 3,109 patients were included. The pooled results indicated that patients with high VDR expression generally had better overall survival (OS) (pooled HR = 0.67; 95% CI = 0.53-0.85; P = 0.001). Subgroup analyses showed that tumour type was the variable affecting the association between VDR expression and OS. VDR expression in colorectal cancer was not associated with OS (pooled HR = 0.84; 95% CI = 0.68-1.03; P = 0.086). We eliminated publication bias using the "trim and fill" method and found that high VDR expression remained an indicator of good OS (P = 0.001). Only a few studies explored the relationship between VDR expression and cancer-specific survival (CSS) or progression-free survival (PFS), and the pooled results indicated no association between them (P>0.05). VDR expression is a prognostic indicator in digestive system tumours and may also be used as a reference for vitamin D supplementation. Detection of VDR expression not only helps to evaluate prognosis but also to formulate more precise treatment plans for patients with digestive system tumours.
维生素 D 受体（VDR）在多种消化系统肿瘤中的预后价值仍存在争议。有鉴于此，我们进行了一项荟萃分析。检索截至 2023 年 3 月 30 日评估 VDR 在消化系统肿瘤中预后作用的已发表研究。根据纳入研究中提取的高 VDR 表达的风险比（HR）进行汇总分析。如果存在异质性，则使用随机效应模型；否则，使用固定效应模型。进行亚组分析、敏感性分析和荟萃回归分析，以探讨异质性的来源。纳入了 8 项研究，共 3109 例患者。汇总结果表明，高 VDR 表达的患者总体生存（OS）通常较好（汇总 HR = 0.67；95%CI = 0.53-0.85；P = 0.001）。亚组分析显示，肿瘤类型是影响 VDR 表达与 OS 之间关系的变量。结直肠癌中 VDR 表达与 OS 无关（汇总 HR = 0.84；95%CI = 0.68-1.03；P = 0.086）。我们使用“修剪和填充”方法消除了发表偏倚，发现高 VDR 表达仍然是 OS 良好的指标（P = 0.001）。只有少数研究探讨了 VDR 表达与癌症特异性生存（CSS）或无进展生存（PFS）之间的关系，汇总结果表明它们之间无关联（P>0.05）。VDR 表达是消化系统肿瘤的预后指标，也可作为维生素 D 补充的参考。检测 VDR 表达不仅有助于评估预后，还有助于为消化系统肿瘤患者制定更精确的治疗计划。
