Regirer S A, Tsaturian A K, Chernaia G G
Biofizika. 1986 Jul-Aug;31(4):667-71.
In order to describe spontaneous wave-like contractions of a single isolated cardiomyocyte a mathematical model is proposed, which relates this phenomenon to propagation of calcium ion concentration wave along the cell. Free diffusion of Ca2+ ions as well as their reversible binding to regulatory proteins in contractile apparatus, Ca2+ accumulation in sarcoplasmic reticulum, and Ca-induced Ca2+ release are included in the governing equations. The model agrees with some observations. It predicts also some effects which may by a subject of future experimental research.
为了描述单个分离心肌细胞的自发波状收缩，提出了一个数学模型，该模型将此现象与钙离子浓度波沿细胞的传播联系起来。控制方程中包括Ca2+离子的自由扩散、它们与收缩装置中调节蛋白的可逆结合、Ca2+在肌浆网中的积累以及钙诱导的Ca2+释放。该模型与一些观察结果相符。它还预测了一些可能成为未来实验研究对象的效应。
