当微生物消失时：了解肠道微生物组多样性丧失的影响。

When microbes go missing: Understanding the impact of diversity loss within the gut microbiome.

机构信息

Department of Ecology & Evolutionary Biology, Cornell University, Ithaca, NY, USA.

Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, UK.

出版信息

Cell Host Microbe. 2023 Aug 9;31(8):1249-1251. doi: 10.1016/j.chom.2023.07.006.

DOI:10.1016/j.chom.2023.07.006

PMID:37562357

Abstract

Two recent papers published in Cell highlight the power of both top-down and bottom-up approaches to understanding the gut microbiome. The first uses ultra-deep sequencing to identify patterns across a gradient of human industrialization, while the second uses synthetic communities to determine how strain interactions impact microbiome structure and function.

摘要

最近发表在《Cell》上的两篇论文强调了自上而下和自下而上两种方法在理解肠道微生物组方面的强大作用。第一篇文章利用超深度测序技术，在人类工业化的梯度上识别出各种模式，而第二篇文章则利用合成群落来确定菌株相互作用如何影响微生物组的结构和功能。