寻求古老智慧，发现新型 AMP。
Seeking old wisdoms for new AMP discovery.
机构信息
CAS Key Lab for Pathogenic Microbiology and Immunology, Institute of Microbiology, CAS, Beijing 100101, China.
出版信息
Cell Host Microbe. 2023 Aug 9;31(8):1251-1253. doi: 10.1016/j.chom.2023.06.017.
PMID:37562358
Abstract
In this issue of Cell Host & Microbe, Maasch et al. built a deep-learning model for proteolytic site prediction and applied this approach to modern and extinct human proteomes, revealing antimicrobial peptides. The de-extinction of archaic encrypted peptides provides a revolutionary approach for discovering functional peptides with therapeutic potential.
摘要
在本期《细胞宿主与微生物》中，Maasch 等人构建了一个用于蛋白酶切割位点预测的深度学习模型，并将该方法应用于现代和已灭绝的人类蛋白质组，揭示了抗菌肽。古代加密肽的复活提供了一种革命性的方法，可以发现具有治疗潜力的功能肽。
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