Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
J Biol Chem. 2023 Sep;299(9):105146. doi: 10.1016/j.jbc.2023.105146. Epub 2023 Aug 9.
The Maintenance of outer membrane (OM) Lipid Asymmetry system mediates retrograde phospholipid transport from the OM to the inner membrane (IM) in Gram-negative bacteria. However, the interactions between the various subunits of the IM and OM complexes are not well understood. In a recent study in 2023 by MacRae et al. in the Journal of Biological Chemistry, the authors examine components in the Maintenance of OM Lipid Asymmetry complex, define the interaction interfaces between members of the pathway, and propose a molecular model of the lipid transfer process from the OM to the IM that will help elucidate intricacies of lipid transport.
革兰氏阴性菌的外膜（OM）脂质不对称系统维持将磷脂从 OM 逆向转运到内膜（IM）。然而，IM 和 OM 复合物的各个亚基之间的相互作用还不是很清楚。在 2023 年 MacRae 等人发表在《生物化学杂志》上的一项最新研究中，作者研究了维持 OM 脂质不对称复合物的成分，确定了该途径成员之间的相互作用界面，并提出了一个从 OM 到 IM 的脂质转移过程的分子模型，这将有助于阐明脂质转运的复杂性。
