From the Center for Magnetic Resonance in Biology and Medicine (B.T., N.F., S.D., S.M., N.L.M., J.P., M.G., B.A., J.P.S., V.C.), Aix-Marseille University, Centre national de la recherche scientifique, Marseille, France
Assistance Publique-Hopitaux de Marseille (B.T., N.F., S.D., S.M., N.L.M., J,P., M.G., B.A., J.P.S., V.C.), Hôpital Universitaire Timone, CEMEREM, Marseille, France.
AJNR Am J Neuroradiol. 2023 Sep;44(9):1101-1107. doi: 10.3174/ajnr.A7964. Epub 2023 Aug 10.
The detection of spinal cord lesions in patients with MS is challenging. Recently, the 3D MP2RAGE sequence demonstrated its usefulness at 3T. Benefiting from the high spatial resolution provided by ultra-high-field MR imaging systems, we aimed to evaluate the contribution of the 3D MP2RAGE sequence acquired at 7T for the detection of MS lesions in the cervical spine.
Seventeen patients with MS participated in this study. They were examined at both 3T and 7T. The MR imaging examination included a Magnetic Imaging in MS (MAGNIMS) protocol with an axial T2*-WI gradient recalled-echo sequence ("optimized MAGNIMS protocol") and a 0.9-mm isotropic 3D MP2RAGE sequence at 3T, as well as a 0.7-mm isotropic and 0.3-mm in-plane-resolution anisotropic 3D MP2RAGE sequences at 7T. Each data set was read by a consensus of radiologists, neurologists, and neuroscientists. The number of lesions and their topography, as well as the visibility of the lesions from one set to another, were carefully analyzed.
A total of 55 lesions were detected. The absolute number of visible lesions differed among the 4 sequences (linear mixed effect ANOVA, = .020). The highest detection was observed for the two 7T sequences with 51 lesions each (92.7% of the total). The optimized 3T MAGNIMS protocol and the 3T MP2RAGE isotropic sequence detected 41 (74.5%) and 35 lesions (63.6%), respectively.
The 7T MP2RAGE sequences detected more lesions than the 3T sets. Isotropic and anisotropic acquisitions performed comparably. Ultra-high-resolution sequences obtained at 7T improve the identification and delineation of lesions of the cervical spinal cord in MS.
在 MS 患者中检测脊髓病变具有挑战性。最近，3D MP2RAGE 序列在 3T 中显示出其有用性。受益于超高场磁共振成像系统提供的高空间分辨率，我们旨在评估在 7T 下采集的 3D MP2RAGE 序列对检测 MS 颈椎病变的贡献。
17 例 MS 患者参与了这项研究。他们在 3T 和 7T 下进行了检查。磁共振成像检查包括轴向 T2*-WI 梯度回波序列的磁成像多发性硬化症（MAGNIMS）方案（“优化 MAGNIMS 方案”）和 3T 上的 0.9mm 各向同性 3D MP2RAGE 序列，以及 7T 上的 0.7mm 各向同性和 0.3mm 面内分辨率各向异性 3D MP2RAGE 序列。每个数据集都由放射科医生、神经科医生和神经科学家进行共识阅读。仔细分析了病变的数量及其分布，以及从一组到另一组的病变可见性。
共发现 55 个病变。4 种序列之间可见病变的绝对数量存在差异（线性混合效应方差分析，F =.020）。两种 7T 序列的检测率最高，各有 51 个病变（占总数的 92.7%）。优化的 3T MAGNIMS 方案和 3T MP2RAGE 各向同性序列分别检测到 41 个（74.5%）和 35 个病变（63.6%）。
7T MP2RAGE 序列比 3T 序列检测到更多的病变。各向同性和各向异性采集结果相当。在 7T 下获得的超高分辨率序列可提高 MS 颈椎病变的识别和描绘。
