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验证 EuroSCORE II 在 KROK 注册中心心房颤动心脏手术患者中的应用。

Validation of EuroSCORE II in atrial fibrillation heart surgery patients from the KROK Registry.

机构信息

Department of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.

Clinical Department of Cardiac Surgery and Transplantology, National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland.

出版信息

Sci Rep. 2023 Aug 10;13(1):13024. doi: 10.1038/s41598-023-39983-w.

DOI:10.1038/s41598-023-39983-w
PMID:37563207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10415263/
Abstract

The study aimed to validate the European System for Cardiac Operative Risk Evaluation score (EuroSCORE II) in patients with atrial fibrillation (AF). All data were retrieved from the National Registry of Cardiac Surgery Procedures (KROK). EuroSCORE II calibration and discrimination performance was evaluated. The final cohort consisted of 44,172 patients (median age 67, 30.8% female, 13.4% with AF). The in-hospital mortality rate was 4.14% (N = 1830), and 5.21% (N = 2303) for 30-day mortality. EuroSCORE II significantly underestimated mortality in mild- and moderate-risk populations [Observed (O):Expected (E)-1.1, 1.16). In the AF subgroup, it performed well [O:E-0.99), whereas in the very high-risk population overestimated mortality (O:E-0.9). EuroSCORE II showed better discrimination in AF (-) [area under curve (AUC) 0.805, 95% CI 0.793-0.817)] than in AF (+) population (AUC 0.791, 95%CI 0.767-0.816), P < 0.001. The worst discriminative performance for the AF (+) group was for coronary artery bypass grafting (CABG) (AUC 0.746, 95% CI 0.676-0.817) as compared with AF (-) population (AUC 0.798, 95% CI 0.774-0.822), P < 0.001. EuroSCORE II is more accurate for patients with AF. However, it underestimated mortality rates for low-to-moderate-risk patients and had a lower ability to distinguish between high- and low-risk patients with AF, particularly in those undergoing coronary artery bypass grafting.

摘要

本研究旨在验证房颤(AF)患者的欧洲心脏手术风险评估系统评分(EuroSCORE II)。所有数据均从国家心脏手术程序登记处(KROK)中获取。评估了 EuroSCORE II 的校准和区分性能。最终队列包括 44172 名患者(中位数年龄为 67 岁,30.8%为女性,13.4%为 AF)。院内死亡率为 4.14%(N=1830),30 天死亡率为 5.21%(N=2303)。EuroSCORE II 显著低估了轻度和中度风险人群的死亡率[观察值(O):预期值(E)-1.1,1.16]。在 AF 亚组中,它表现良好[O:E-0.99],而在极高风险人群中则高估了死亡率(O:E-0.9)。EuroSCORE II 在 AF(-)组中的区分度更好[曲线下面积(AUC)0.805,95%置信区间 0.793-0.817],而在 AF(+)人群中的区分度较差(AUC 0.791,95%CI 0.767-0.816),P<0.001。对于 AF(+)组,冠状动脉旁路移植术(CABG)的区分性能最差(AUC 0.746,95%CI 0.676-0.817),而 AF(-)人群的区分性能较好(AUC 0.798,95%CI 0.774-0.822),P<0.001。EuroSCORE II 对 AF 患者更准确。然而,它低估了低至中度风险患者的死亡率,并且在区分 AF 高危和低危患者方面能力较低,尤其是在接受冠状动脉旁路移植术的患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a57/10415263/94a9f3229fff/41598_2023_39983_Fig6_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a57/10415263/370af2536530/41598_2023_39983_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a57/10415263/3abbca7984dc/41598_2023_39983_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a57/10415263/52ecf6c7b86a/41598_2023_39983_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a57/10415263/94a9f3229fff/41598_2023_39983_Fig6_HTML.jpg

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