转录和复制与失活的X染色体区域相遇。 - Suppr

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超能文献

Transcription and replication meet the silent X chromosome territory.

作者信息

Zimmer Frederic, Basilicata M Felicia, Keller Valsecchi Claudia Isabelle

机构信息

Institute of Molecular Biology (IMB), Mainz, Germany.

DFG-Research Training Group 2526 'GenEvo', Mainz, Germany.

出版信息

Nat Struct Mol Biol. 2023 Aug;30(8):1054-1056. doi: 10.1038/s41594-023-01054-z.

DOI:10.1038/s41594-023-01054-z

PMID:37563441

Abstract

摘要

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本文引用的文献

Replication dynamics identifies the folding principles of the inactive X chromosome.复制动力学确定了失活 X 染色体的折叠原则。

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RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization.RNA 聚合酶 II 从失活 X 染色体区域的耗竭不是由物理分隔介导的。

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Simultaneous mapping of 3D structure and nascent RNAs argues against nuclear compartments that preclude transcription.同时绘制 3D 结构和新生 RNA 图谱，驳斥了那些阻止转录的核隔室。

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Xist nucleates local protein gradients to propagate silencing across the X chromosome.Xist 引发局部蛋白质梯度，在 X 染色体上传播沉默。

Cell. 2021 Dec 9;184(25):6174-6192.e32. doi: 10.1016/j.cell.2021.10.022. Epub 2021 Nov 4.

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