Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Center for Translational Neuroscience, Isfahan University of Medical Sciences, Isfahan, Iran.
Sci Rep. 2023 Aug 10;13(1):13045. doi: 10.1038/s41598-023-40327-x.
Behavioral aspects and underlying pathology of attention deficit in multiple sclerosis (MS) remain unknown. This study aimed to clarify impairment of attention and its relationship with MS-related fatigue. Thirty-four relapse-remitting MS (RRMS), 35 secondary-progressive MS (SPMS) and 45 healthy controls (HC) were included. Results of psychophysics tasks (attention network test (ANT) and Posner spatial cueing test) and fatigue assessments (visual analogue scale and modified fatigue impact scale (MFIS)) were compared between groups. In ANT, attentional network effects were not different between MS phenotypes and HC. In Posner task, RRMS or SPMS patients did not benefit from valid cues unlike HC. RRMS and SPMS patients had less gain in exogenous trials with 62.5 ms cue-target interval time (CTIT) and endogenous trials with 250 ms CTIT, respectively. Total MFIS was the predictor of gain in 250 ms endogenous blocks and cognitive MFIS predicted orienting attentional effect. Executive attentional effect in RRMS patients with shorter disease duration and orienting attentional effect in longer diagnosed SPMS were correlated with MFIS scores. The pattern of attention deficit in MS differs between phenotypes. Exogenous attention is impaired in RRMS patients while SPMS patients have deficit in endogenous attention. Fatigue trait predicts impairment of endogenous and orienting attention in MS.
多发性硬化症（MS）患者的注意力缺陷行为方面和潜在病理学仍不清楚。本研究旨在阐明注意力损伤及其与 MS 相关疲劳的关系。共纳入 34 例复发缓解型 MS（RRMS）、35 例继发进展型 MS（SPMS）和 45 例健康对照者（HC）。比较了各组之间的心理物理学任务（注意网络测试（ANT）和 Posner 空间线索测试）和疲劳评估（视觉模拟量表和改良疲劳影响量表（MFIS））结果。在 ANT 中，MS 表型与 HC 之间的注意力网络效应没有差异。在 Posner 任务中，RRMS 或 SPMS 患者与 HC 不同，无法从有效线索中获益。RRMS 和 SPMS 患者在外源性试验（62.5ms 线索-靶间隔时间（CTIT））和内源性试验（250ms CTIT）中获益较少。总 MFIS 是 250ms 内源性块增益的预测因子，认知 MFIS 预测定向注意力效应。RRMS 患者的疾病持续时间较短的执行注意力效应和 SPMS 患者的诊断时间较长的定向注意力效应与 MFIS 评分相关。MS 患者的注意力缺陷模式在表型之间存在差异。RRMS 患者的外源性注意力受损，而 SPMS 患者的内源性注意力受损。疲劳特征预测 MS 患者内源性和定向注意力损伤。
