Department of General Surgery, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, 200433, China.
Department of Emergency, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, 200433, China.
World J Surg Oncol. 2023 Aug 11;21(1):245. doi: 10.1186/s12957-023-03137-z.
Currently, the characteristics and prognosis of remnant gastric cancer (RGC) are not fully understood yet. The present study aimed to describe the details of clinicopathological features of resectable RGC and investigated the factors affecting survival after the curative operation.
From Jan. 2006 to Dec. 2015, a total of 118 resectable RGC patients (the RGC group) and 236 age-, sex- and TNM stages-matched resectable gastric cancer (GC) patients (the control group) were recruited retrospectively. Clinicopathological characteristics and overall survival were compared between the two groups.
The overall survival rate was 46.61% for RGC patients compared to 55.08% for control groups (P < 0.01), and the mean overall survival time of RGC patients was 40.23 ± 32.27 months, compared to 55.06 ± 34.29 months in the control group (P = 0.023 after matching). The overall survival (OS) of RGC patients with stage IIb was much worse than IIa (P < 0.001) and similar to IIIa (P = 0.463) and IIIb (P = 0.014). Multivariate Cox proportional hazards model analysis revealed that TNM stage (HR: 3.899, P < 0.001) and lymph nodes ratio (LNR) (HR: 2.405, P = 0.028) were independent prognostic significance to OS.
The OS of RGC was much worse than GC with similar TNM stages, and LNR might consider a highly reliable indicator to evaluate the prognostic in RGC.
目前，人们对残胃癌（RGC）的特征和预后尚不完全了解。本研究旨在描述可切除 RGC 的临床病理特征，并探讨影响根治性手术后生存的因素。
回顾性分析 2006 年 1 月至 2015 年 12 月收治的 118 例可切除 RGC 患者（RGC 组）和 236 例年龄、性别和 TNM 分期匹配的可切除胃癌（GC）患者（对照组）的临床病理特征和总生存期。
RGC 患者的总生存率为 46.61%，对照组为 55.08%（P<0.01），RGC 患者的平均总生存时间为 40.23±32.27 个月，对照组为 55.06±34.29 个月（匹配后 P=0.023）。RGC 患者的 IIb 期总生存（OS）明显差于 IIa 期（P<0.001），与 IIIa 期（P=0.463）和 IIIb 期（P=0.014）相似。多因素 Cox 比例风险模型分析显示，TNM 分期（HR：3.899，P<0.001）和淋巴结比率（LNR）（HR：2.405，P=0.028）是 OS 的独立预后因素。
RGC 的 OS 明显差于具有相似 TNM 分期的 GC，LNR 可能是评估 RGC 预后的一个高度可靠指标。
