Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China.
The Second Hospital of Jilin University, Changchun, P.R. China.
Ren Fail. 2023 Dec;45(1):2238830. doi: 10.1080/0886022X.2023.2238830.
Methods for early prediction of the occurrence of acute kidney injury (AKI) were limited. The relationship between triglyceride glucose index (TyG) and the incidence of acute kidney injury in ICU patients is unclear. This study aims to explore the relationship between the two.
Based on their TyG index, participants from the Intensive Care Medical Information Market IV (MIMIC-IV) were divided into quartiles. A logistic regression model was constructed based on the risk of acute kidney injury as the main outcome, in order to detect a potential relationship that may exist between the TyG index and acute kidney injury in ICU patients. Finally, in order to confirm the relationship existing between the TyG index and the results, a restricted cubic spline model was used.
In total, 54,263 patients were involved in our present study, of whom 48.2% were male. The occurrence of acute kidney injury was 25.1%. An independent relationship was observed between the TyG index and an increased risk of acute kidney injury through multivariate logistic regression analysis (OR, 1.28 [95% CI 1.22-1.35] < 0.001). Q4 (5.344-9.911) of the TyG index quartiles was independently associated with an increase in the risk of acute kidney injury (OR, 1.43 [95% CI (1.32-1.54)] < 0.001). Through the restricted cubic spline regression model, the risk of acute kidney injury was also demonstrated to increase linearly with an increase in the TyG index.
The triglyceride glucose index is related to the risk of acute kidney injury in ICU patients. In the future, in order to further validate this finding, larger prospective studies are needed.
急性肾损伤（AKI）发生的早期预测方法有限。甘油三酯-葡萄糖指数（TyG）与 ICU 患者急性肾损伤发生的关系尚不清楚。本研究旨在探讨两者之间的关系。
根据 TyG 指数，从 Intensive Care Medical Information Market IV（MIMIC-IV）中划分参与者四分位数。构建基于急性肾损伤风险作为主要结局的逻辑回归模型，以检测 TyG 指数与 ICU 患者急性肾损伤之间可能存在的潜在关系。最后，为了确认 TyG 指数与结果之间存在的关系，使用限制性立方样条模型。
本研究共纳入 54263 名患者，其中 48.2%为男性。急性肾损伤的发生率为 25.1%。通过多变量逻辑回归分析观察到 TyG 指数与急性肾损伤风险增加之间存在独立关系（OR，1.28[95%CI 1.22-1.35] < 0.001）。TyG 指数四分位数 Q4（5.344-9.911）与急性肾损伤风险增加独立相关（OR，1.43[95%CI （1.32-1.54）] < 0.001）。通过限制性立方样条回归模型，也证明了急性肾损伤的风险随着 TyG 指数的增加呈线性增加。
甘油三酯-葡萄糖指数与 ICU 患者急性肾损伤的风险相关。未来需要更大规模的前瞻性研究来进一步验证这一发现。
