Weiss J, Goldberg M P, Choi D W
Brain Res. 1986 Aug 13;380(1):186-90. doi: 10.1016/0006-8993(86)91447-2.
The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-D-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.
据最近报道，全身麻醉剂氯胺酮可阻断N-甲基-D-天冬氨酸（NMDA）对皮质神经元的兴奋作用，研究发现，在暴露于低氧环境或氰化物的小鼠新皮质细胞培养物中，氯胺酮能显著减少神经元损失。这些观察结果可能与在临床环境中寻找将缺氧性脑损伤降至最低的药理学方法的尝试相关。
