Takahata Y, Shimoji K
Brain Res. 1986 Sep 3;381(2):368-71. doi: 10.1016/0006-8993(86)90091-0.
Minor brain injury was inflicted with a small needle at 4 sites one week before the production of incomplete brain ischemia in the mouse. A bilateral carotid clamp was applied for 60 min under pentobarbital anesthesia, and the number of survivors at one week after the ischemic insult was compared with those in animals anesthetized only and those in a sham-operated group. The number of survivors in the brain-injured group was significantly higher than in the other two groups. The results suggest that anti-ischemic factors are released by the injured brain or that certain unknown protective mechanisms against ischemia become active following brain injury.
在小鼠制造不完全性脑缺血前一周，用小针在4个部位造成轻度脑损伤。在戊巴比妥麻醉下进行双侧颈动脉夹闭60分钟，并将缺血损伤一周后的存活动物数量与仅接受麻醉的动物及假手术组动物进行比较。脑损伤组的存活动物数量显著高于其他两组。结果表明，损伤的脑释放了抗缺血因子，或者脑损伤后某些未知的抗缺血保护机制被激活。
