牛脑动脉中血管活性肠肽（VIP）结合位点的放射自显影定位
Autoradiographic localization of binding sites for vasoactive intestinal peptide (VIP) in bovine cerebral arteries.
作者信息
Poulin P, Suzuki Y, Lederis K, Rorstad O P
出版信息
Brain Res. 1986 Sep 3;381(2):382-4. doi: 10.1016/0006-8993(86)90094-6.
A substantial body of published evidence indicates that vasoactive intestinal peptide (VIP) may function as a vasodilatory neurotransmitter to cerebral blood vessels via a specific VIP receptor. In the present study in vitro autoradiography utilizing monoiodinated [125I-Tyr10]-VIP demonstrated VIP binding sites in the medial layer of bovine anterior, middle, and posterior cerebral arteries. This observation is consistent with the VIP receptor being localized in vascular smooth muscle components.
大量已发表的证据表明，血管活性肠肽（VIP）可能通过特定的VIP受体作为脑血管的血管舒张性神经递质发挥作用。在本项体外放射自显影研究中，利用单碘化的[125I-酪氨酸10]-VIP证实了牛大脑前、中、后动脉中层存在VIP结合位点。这一观察结果与VIP受体定位于血管平滑肌成分相一致。
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