Grigonis A M, Pearson H E, Murphy E H
Brain Res. 1986 Sep;394(1):9-19. doi: 10.1016/0165-3806(86)90077-5.
Autoradiographic methods were used to compare the ipsilateral and contralateral retinothalamic projections in pigmented Dutch-Belted rabbits that had neonatal monocular enucleation with the projections found in normally reared rabbits. In the normal adult rabbit, there is dense label throughout the dorsal lateral geniculate nucleus (LGd) except for a decreased label density in the region corresponding to the ipsilateral input. Following neonatal monocular enucleation, the contralateral projection fills in the part of the LGd corresponding to the ipsilateral input. Our data indicate that following monocular enucleation, two processes occur: an arrest of the segregation process and an expansion of the contralateral projection into the space normally containing the terminals of the ipsilateral projection. In addition, this filling in of the terminal space occurs relatively rapidly and is completed by day 14. No changes, however, were observed in the ipsilateral projection to the LGd. Unlike the LGd, the ventral lateral geniculate nucleus and the intergeniculate leaflet showed increases in the size of the ipsilateral projection region, and no changes in the contralateral projection. The present findings suggest that there may be different mechanisms governing whether alterations in the distribution of retinothalamic projections will occur in either the ipsilateral or contralateral nucleus.
采用放射自显影方法，比较新生期单眼摘除的有色荷兰带兔同侧和对侧视网膜丘脑投射与正常饲养兔的投射情况。在正常成年兔中，整个背侧外侧膝状体核（LGd）有密集标记，但对应同侧输入的区域标记密度降低。新生期单眼摘除后，对侧投射填充了LGd中对应同侧输入的部分。我们的数据表明，单眼摘除后会发生两个过程：分离过程停止，对侧投射扩展到通常包含同侧投射终末的空间。此外，这种终末空间的填充相对较快，在第14天完成。然而，向LGd的同侧投射未观察到变化。与LGd不同，腹侧外侧膝状体核和膝间小叶同侧投射区域的大小增加，对侧投射无变化。目前的研究结果表明，可能存在不同机制来控制视网膜丘脑投射分布的改变是否会在同侧或对侧核中发生。
