Health Sciences University, Haseki Training and Research Hospital, Department of Endocrinology, Fatih, Istanbul, Turkey.
Medicine (Baltimore). 2023 Aug 11;102(32):e34564. doi: 10.1097/MD.0000000000034564.
The study aimed to evaluate the ABO/Rh blood group distributions and their relationship with clinical-pathological features in papillary thyroid cancer patients. It was planned as a retrospective case-controlled study. The blood group distributions of the patients were contrasted with that of the general population. Additionally, the association between clinical-pathological variables and blood group distribution was assessed. Two hundred and ninety-three patients were involved in the study. The median age was 48 years, and the majority of patients were female (84.3%). The most common variants of papillary thyroid cancer were follicular, classical, and oncocytic. The majority of the patients had stage 1 (91.1%) disease at the time of diagnosis. ABO blood group distributions in the patient (47.4% A, 11.9% B, 8.2% AB, 32.4% O) and control (42% A, 16% B, 8% AB, 34% O) groups were found to be similar ( P = .8). In terms of Rh factor, there was a comparable distribution for the characteristics of the patient and healthy control group ( P = .6). There was no association between clinical and pathological variables and blood group distributions (gender, age, tumor stage, tumor location, and pathological tumor variant). Comparing patients with papillary thyroid carcinoma to the healthy control group, the prevalence of the A blood group numerically increased while the prevalence of the B blood group numerically decreased, but it was not statistically significant. In addition, ABO/Rh blood type and clinical and pathological variables did not relate.
本研究旨在评估 ABORh 血型分布及其与甲状腺乳头状癌患者临床病理特征的关系。该研究计划采用回顾性病例对照研究。将患者的血型分布与普通人群进行对比。此外，还评估了临床病理变量与血型分布之间的关系。该研究共纳入 293 例患者。中位年龄为 48 岁，大多数患者为女性（84.3%）。甲状腺乳头状癌最常见的变异型为滤泡型、经典型和嗜酸细胞型。大多数患者在诊断时处于 1 期（91.1%）疾病。患者（47.4%A、11.9%B、8.2%AB、32.4%O）和对照组（42%A、16%B、8%AB、34%O）的 ABO 血型分布相似（P=0.8）。就 Rh 因子而言，患者和健康对照组的特征分布相似（P=0.6）。临床和病理变量与血型分布之间没有关联（性别、年龄、肿瘤分期、肿瘤位置和病理肿瘤变异）。与健康对照组相比，甲状腺乳头状癌患者 A 血型的患病率略有增加，B 血型的患病率略有下降，但无统计学意义。此外，ABORh 血型与临床和病理变量无关。
