Al-Khazali Haidar M, Christensen Rune Häckert, Lambru Giorgio, Dodick David W, Ashina Håkan
Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Curr Pain Headache Rep. 2023 Oct;27(10):543-550. doi: 10.1007/s11916-023-01156-9. Epub 2023 Aug 11.
Hemicrania Continua (HC) is a rare and disabling primary headache disorder that is characterized by persistent, unilateral headache with ipsilateral, cranial autonomic symptoms and restlessness or agitation. The diagnosis requires patients to experience an absolute response to therapeutic doses of indomethacin.
HC is diagnosed in in about 1.8% of adult patients who were evaluated for headache in tertiary care services, albeit this estimate should be interpreted with caution. The most prevalent accompanying symptoms appear to be lacrimation, conjunctival injection and restlessness or agitation. However, the available literature is limited by methodologic issues, and the current diagnostic criteria lack clarity on what defines absolute response to indomethacin. More rigorous studies are thus needed to improve our understanding of HC which, in turn, will facilitate better disease management in clinical practice. Here, we provide a comprehensive overview of HC, including its epidemiology, clinical presentation, diagnostic evaluation, and management.
持续性偏侧头痛（HC）是一种罕见且致残的原发性头痛疾病，其特征为持续性单侧头痛，并伴有同侧颅神经自主症状以及烦躁不安或激动。诊断要求患者对治疗剂量的消炎痛有绝对反应。
在三级医疗服务机构接受头痛评估的成年患者中，约1.8%被诊断为HC，不过这一估计应谨慎解读。最常见的伴随症状似乎是流泪、结膜充血以及烦躁不安或激动。然而，现有文献受方法学问题限制，当前诊断标准对于消炎痛绝对反应的定义尚不明确。因此，需要更严谨的研究来增进我们对HC的理解，进而有助于在临床实践中更好地管理该疾病。在此，我们对HC进行全面概述，包括其流行病学、临床表现、诊断评估及管理。
