Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Surgical Center, University of Yamanashi Hospital, University of Yamanashi, Chuo, Yamanashi, Japan.
J Anesth. 2023 Dec;37(6):835-840. doi: 10.1007/s00540-023-03240-1. Epub 2023 Aug 11.
Perioperative shivering is common and can occur as a result of hypothermia or changes in the threshold of thermoregulation. Droperidol usage for anesthesia is currently limited to its sedative and antiemetic effects. We investigated the effects of high and low doses of droperidol on the shivering threshold in rabbits.
Forty-two male Japanese white rabbits were anesthetized with isoflurane and randomly assigned to the control, high-dose, or low-dose group. Rabbits in the high-dose group received a 5 mg/kg droperidol bolus followed by continuous infusion at 5 mg/kg/h, those in the low-dose group received a 0.5 mg/kg droperidol bolus, and those in the control group received the same volume of saline as the high-dose group. Body temperature was reduced at a rate of 2-3 °C/h, and the shivering threshold was defined as the subject's core temperature (°C) at the onset of shivering.
The shivering thresholds in the control, high-dose, and low-dose groups were 38.1 °C ± 1.1 °C, 36.7 °C ± 1.2 °C, and 36.9 °C ± 1.0 °C, respectively. The shivering thresholds were significantly lower in the high-dose and low-dose groups than in the control group (P < 0.01). The thresholds were comparable between the high-dose and low-dose groups.
Droperidol in high and low doses effectively reduced the shivering threshold in rabbits. Droperidol has been used in low doses as an antiemetic. Low doses of droperidol can reduce the incidence of shivering perioperatively and during the induction of therapeutic hypothermia.
围手术期寒战很常见，可能是由于体温过低或体温调节阈值变化引起的。氟哌利多在麻醉中的应用目前仅限于其镇静和止吐作用。我们研究了氟哌利多高、低剂量对兔寒战阈值的影响。
42 只雄性日本白兔用异氟烷麻醉，并随机分为对照组、高剂量组或低剂量组。高剂量组兔给予 5mg/kg 氟哌利多推注，然后以 5mg/kg/h 的速度持续输注；低剂量组兔给予 0.5mg/kg 氟哌利多推注；对照组兔给予与高剂量组相同体积的生理盐水。以 2-3°C/h 的速度降低体温，寒战阈值定义为兔寒战开始时的核心体温（°C）。
对照组、高剂量组和低剂量组的寒战阈值分别为 38.1°C±1.1°C、36.7°C±1.2°C和 36.9°C±1.0°C。高剂量组和低剂量组的寒战阈值明显低于对照组（P<0.01）。高剂量组和低剂量组之间的阈值无差异。
氟哌利多高、低剂量均可有效降低兔的寒战阈值。氟哌利多已被低剂量用作止吐药。低剂量氟哌利多可减少围手术期和治疗性低温诱导期间寒战的发生率。
