血管紧张素II长期输注和撤除对自发性高血压大鼠的影响。

The effect of prolonged infusion and withdrawal of angiotensin II in the spontaneously hypertensive rat.

作者信息

Chiu E K, McNeill J R

出版信息

Can J Physiol Pharmacol. 1986 Jun;64(6):748-50. doi: 10.1139/y86-126.

Abstract

In spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto controls (WKY), prolonged intravenous administration of angiotensin II (AII, 0.2 microgram X kg-1 X min-1 for 3h) resulted in similar increases in arterial blood pressure. Heart rate decreased in WKY and increased in SHR. At the end of the infusion, blood pressure dropped substantially in SHR, but not in WKY: at 5 h after AII withdrawal, blood pressure in SHR had fallen from a control value of 172 +/- 3.3 to 146 +/- 3.9 mmHg (p less than 0.01), whereas pressure in WKY had fallen from 116 +/- 3.0 to 107 +/- 4.2 mmHg (statistically non significant). Thus, pressure at 5 h after AII withdrawal was still substantially higher (p less than 0.01) in the SHR than in the WKY. The results demonstrate that the fall in blood pressure following withdrawal of a prolonged infusion of AII in SHR is much less than that reported to occur following withdrawal of a prolonged infusion of vasopressin (AVP) in SHR.

摘要

在自发性高血压大鼠（SHR）及其血压正常的Wistar-Kyoto对照大鼠（WKY）中，长时间静脉注射血管紧张素II（AII，0.2微克×千克-1×分钟-1，持续3小时）导致动脉血压出现相似程度的升高。WKY的心率下降，而SHR的心率升高。在输注结束时，SHR的血压大幅下降，但WKY的血压未下降：在停用AII后5小时，SHR的血压从对照值172±3.3 mmHg降至146±3.9 mmHg（p<0.01），而WKY的血压从116±3.0 mmHg降至107±4.2 mmHg（无统计学意义）。因此，停用AII后5小时，SHR的血压仍显著高于WKY（p<0.01）。结果表明，在SHR中，长时间输注AII后停药时血压的下降幅度远小于在SHR中长时间输注血管升压素（AVP）后停药时所报告的血压下降幅度。