《妇女健康倡议研究中的双侧卵巢切除术与结直肠癌发病率和死亡率》
Bilateral Oophorectomy and Colorectal Cancer Incidence and Mortality in the Women's Health Initiative.
机构信息
Division of Gynecologic Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California.
Division of Information Sciences, City of Hope National Medical Center, Duarte, California.
出版信息
Cancer Epidemiol Biomarkers Prev. 2023 Nov 1;32(11):1668-1671. doi: 10.1158/1055-9965.EPI-23-0198.
BACKGROUND
The few cohort studies examining oophorectomy and colorectal cancer risk provide mixed results. Therefore, we examined this issue in Women's Health Initiative Observational Study participants.
METHODS
A total of 71,312 postmenopausal women were followed for 22.1 years (median). At enrollment, 55,643 (78%) had intact ovaries and 15,669 (22%) had undergone a bilateral oophorectomy. Colorectal cancers were verified by central medical record review with mortality findings enhanced by National Death Index queries.
RESULTS
With 1,421 incident colorectal cancers, 450 colorectal cancer-specific mortalities, after controlling for covariates, bilateral oophorectomy was not associated with colorectal cancer incidence or colorectal cancer mortality.
CONCLUSIONS
No significant associations between oophorectomy and colorectal cancer incidence and mortality were seen in a large cohort study with long follow-up.
IMPACT
As the oophorectomy and colorectal cancer question remains open, further studies of high quality, even with null findings, should be encouraged.
背景
少数关于卵巢切除术和结直肠癌风险的队列研究结果不一。因此，我们在妇女健康倡议观察研究参与者中研究了这个问题。
方法
共有 71312 名绝经后妇女接受了 22.1 年（中位数）的随访。入组时，55643 名（78%）女性卵巢完整，15669 名（22%）行双侧卵巢切除术。通过中央病历审查验证结直肠癌，通过国家死亡指数查询增强死亡率发现。
结果
在 1421 例结直肠癌病例中，450 例结直肠癌特异性死亡病例中，经协变量调整后，双侧卵巢切除术与结直肠癌发病率或结直肠癌死亡率无关。
结论
在一项随访时间较长的大型队列研究中，卵巢切除术与结直肠癌发病率和死亡率之间没有显著关联。
影响
由于卵巢切除术和结直肠癌的问题仍然存在争议，即使结果为阴性，也应鼓励进行高质量的进一步研究。
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