Nelson Hospital, Te Whatu Ora-Health New Zealand, Ministry of Health, Nelson, New Zealand.
Centre for Translational Physiology, University of Otago, Wellington, New Zealand.
High Alt Med Biol. 2023 Dec;24(4):329-335. doi: 10.1089/ham.2023.0009. Epub 2023 Aug 11.
Barclay, Holly, Saptarshi Mukerji, Bengt Kayser, and Jui-Lin Fan. Appetite, hypoxia and acute mountain sickness: A 10-hour normobaric hypoxic chamber study. . 24:329-335, 2023. The effects of hypoxia and acute mountain sickness (AMS) on appetite and food preferences are moot, especially during the early phase of hypoxic exposure. We examined the effects of a 10-hour hypoxic exposure on appetite and food preference. We assessed appetite (hunger, satisfaction, fullness, perceived appetite, and lost appetite), food preferences (sweet, salty, savory, and fatty), and AMS (Lake Louise score) with questionnaires in 27 healthy individuals (13 women) across 10-hour exposures to normobaric normoxia (fraction of inspired O [FiO]: 0.21) and normobaric hypoxia (FO: 0.12, equivalent of 5,000 m) in a randomized, single-blinded manner. Compared with normoxia, hypoxia decreased hunger and appetite ( = 0.040 and <0.001, respectively), which was mediated by a decreased desire for sweet, salty, and fatty foods ( < 0.05 for all). AMS was associated with a decreased desire for sweet ( = -0.438, = 0.032) and salty foods ( = -0.460, = 0.024) and greater loss of appetite ( = -0.619, = 0.018). Our findings suggest that acute hypoxia rapidly suppresses appetite and that AMS development further amplifies anorexia. Clinical Trial Registration Number: ACTRN12618000548235.
巴克莱、霍利、萨普塔希·穆克吉、本特·凯泽和范菊琳。食欲、缺氧和急性高原病：10 小时常压缺氧舱研究。 24:329-335, 2023. 缺氧和急性高原病 (AMS) 对食欲和食物偏好的影响仍存在争议，尤其是在缺氧暴露的早期阶段。我们研究了 10 小时缺氧暴露对食欲和食物偏好的影响。 我们通过问卷评估了 27 名健康个体（13 名女性）在 10 小时暴露于常压常氧（吸入氧分数 [FiO]：0.21）和常压低氧（FO：0.12，相当于 5000 米）期间的食欲（饥饿感、满意度、饱腹感、感知食欲和食欲减退）、食物偏好（甜、咸、咸和油腻）和 AMS（路易斯湖评分），采用随机、单盲方式。 与常氧相比，缺氧降低了饥饿感和食欲（ = 0.040 和 <0.001，分别），这是通过降低对甜、咸和油腻食物的渴望来介导的（ < 0.05 对所有）。AMS 与对甜食（ = -0.438， = 0.032）和咸食（ = -0.460， = 0.024）的渴望降低以及更大的食欲减退（ = -0.619， = 0.018）相关。我们的研究结果表明，急性缺氧会迅速抑制食欲，而 AMS 的发展进一步加剧了厌食。临床试验注册号：ACTRN12618000548235。
