Internal Medicine Residency Program, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Department of Neurosciences, University of South Dakota Sanford School of Medicine.
S D Med. 2023 Apr;76(4):170-173.
Statins have grown to become an important class of medications in the primary and secondary prevention of cardiovascular diseases. While lowering low-density lipoprotein-C (LDL-C) levels, statins also have a role in stabilization and regression of atherosclerotic plaques. In the last two decades, there is a mounting body of evidence that suggests that statins and lowering serum lipid levels may be associated with an increased risk of developing intracerebral hemorrhage (ICH). This review article provides a concise summary of the most important studies performed to date and the pathophysiology behind the association between statins and ICH.
他汀类药物已成为心血管疾病一级和二级预防的重要药物类别。他汀类药物除了降低低密度脂蛋白胆固醇（LDL-C）水平外，还具有稳定和逆转动脉粥样硬化斑块的作用。在过去的二十年中，越来越多的证据表明，他汀类药物和降低血清脂质水平可能与脑出血（ICH）的风险增加有关。本文综述了迄今为止进行的最重要的研究，并简述了他汀类药物与 ICH 之间的关联的病理生理学基础。
