Carvajal-Elizondo Mariela, Monge-Ortega Olga Patricia, Chinchilla-Monge Ricardo, Quiros Steve
Servicio de Dermatología.
Servicio de Alergología.Caja Costarricense de Seguro Social, Hospital San Juan de Dios, Costa Rica.
Rev Alerg Mex. 2023 May 24;70(1):38-42. doi: 10.29262/ram.v70i1.1047.
Stevens-Johnson syndrome is a severe drug reaction. Sulfonamides have been associated with drug reactions, complications, sequelae, even death.
A 40-year-old female patient with a medical history of endometriosis and recently diagnosed chronic inflammatory ulcerative colitis. She was treated at the Allergology service of the San Juan de Dios Hospital of the Costa Rican Social Security Fund, and after 20 days of treatment with sulfasalazine she had a severe drug reaction on the skin, compatible with Stevens-Johnson syndrome. The lymphocyte transformation test was positive, confirming sulfasalazine as the causative agent.
The lymphocyte transformation test is a useful method that can confirm the causative agent and prevent important complications in the future.
史蒂文斯-约翰逊综合征是一种严重的药物反应。磺胺类药物与药物反应、并发症、后遗症甚至死亡有关。
一名40岁女性患者，有子宫内膜异位病史，近期诊断为慢性炎症性溃疡性结肠炎。她在哥斯达黎加社会保障基金圣胡安·迪奥斯医院的过敏科接受治疗，在用柳氮磺胺吡啶治疗20天后，皮肤出现严重药物反应，符合史蒂文斯-约翰逊综合征。淋巴细胞转化试验呈阳性，证实柳氮磺胺吡啶为致病因素。
淋巴细胞转化试验是一种有用的方法，可确认致病因素并预防未来的重要并发症。
