Huang Li-Bo, Mamiya Fumihiko, Baaden Marc, Yashima Eiji, Barboiu Mihail
Institut Europeen des Membranes, Adaptive Supramolecular Nanosystems Group, University of Montpellier, ENSCM-CNRS, UMR5635, Place E. Bataillon CC047, Montpellier 34095, France.
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China.
ACS Appl Mater Interfaces. 2023 Aug 23;15(33):40133-40139. doi: 10.1021/acsami.3c09059. Epub 2023 Aug 11.
Artificial water channels selectively transport water, excluding all ions. Unimolecular channels have been synthesized via complex synthetic steps. Ideally, simpler compounds requesting less synthetic steps should efficiently lead to selective channels by self-assembly. Herein, we report a self-assembled peptide-bound Ni metallomacrocycle, , in which rim-peptide-bound units are connected to a central macrocycle obtained via condensation in the presence of Ni ions. Compound achieves a single-channel permeability up to 10-10 water/s/channel and insignificant ion transport, which is 1 order of magnitude lower than those for aquaporins. Molecular simulations probe that spongelike aggregates can form to generate transient cluster water pathways through the bilayer. Altogether, adaptive metallosupramolecular self-assembly is an efficient and simple way to construct selective channel superstructures.
人工水通道可选择性地运输水，排斥所有离子。单分子通道是通过复杂的合成步骤合成的。理想情况下，需要较少合成步骤的更简单化合物应能通过自组装有效地形成选择性通道。在此，我们报道了一种自组装的肽结合镍金属大环化合物，其中边缘肽结合单元连接到在镍离子存在下通过缩合获得的中心大环上。化合物实现了高达10-10水/秒/通道的单通道渗透率，且离子运输可忽略不计，这比水通道蛋白低1个数量级。分子模拟表明，海绵状聚集体可以形成，通过双层产生瞬态簇状水通道。总之，适应性金属超分子自组装是构建选择性通道超结构的一种有效且简单的方法。
