Chen Fang-Zhou, Tan Poh-Ching, Yang Zihan, Li Qingfeng, Zhou Shuang-Bai
Department of Plastic & Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital, Shanghai, China.
Department of Plastic and Burn Surgery, West China Hospital of Sichuan University, Chengdu, China.
Clin Exp Dermatol. 2023 Nov 16;48(12):1317-1327. doi: 10.1093/ced/llad257.
Heterogeneous dermal fibroblasts are the main components that constitute the dermis. Distinct fibroblast subgroups show specific characteristics and functional plasticity that determine dermal structure during skin development and wound healing. Although researchers have described the roles of fibroblast subsets, this is not completely understood. We review recent evidence supporting understanding about the heterogeneity of fibroblasts. We summarize the origins and the identified profiles of fibroblast subpopulations. The characteristics of fibroblast subpopulations in both healthy and diseased states are highlighted, and the potential of subpopulations to be involved in wound healing in different ways was discussed. Additionally, we review the plasticity of subpopulations and the underlying signalling mechanisms. This review may provide greater insights into potential novel therapeutic targets and tissue regeneration strategies for the future.
异质性真皮成纤维细胞是构成真皮的主要成分。不同的成纤维细胞亚群表现出特定的特征和功能可塑性，这些特征和可塑性在皮肤发育和伤口愈合过程中决定了真皮结构。尽管研究人员已经描述了成纤维细胞亚群的作用，但对此尚未完全了解。我们综述了支持对成纤维细胞异质性理解的最新证据。我们总结了成纤维细胞亚群的起源和已确定的特征。突出了健康和患病状态下成纤维细胞亚群的特征，并讨论了亚群以不同方式参与伤口愈合的潜力。此外，我们综述了亚群的可塑性及其潜在的信号传导机制。这篇综述可能为未来潜在的新型治疗靶点和组织再生策略提供更深入的见解。
