A reappraisal of the epidemiology of Spitz neoplasms in the molecular era: A retrospective cohort study.

BACKGROUND

Previous studies suggest that Spitz neoplasms occur primarily in younger patients, leading pathologists to shy away from diagnosing a benign Spitz neoplasm in the elderly. With the advent of genomic sequencing, there is a need for reappraisal of the epidemiology of Spitz neoplasms in the modern molecular era.

OBJECTIVE

We aim to reassess the epidemiology of Spitz neoplasms incorporating next-generation sequencing.

METHODS

We looked at 53,814 non-Spitz neoplasms and 1260 Spitz neoplasms including 286 Spitz neoplasms with next-generation sequencing testing and collected various epidemiologic data.

RESULTS

In our general pool of cases, the proportion of Spitz neoplasm cases occurring is relatively the same in each of the first 4 decades of life with a precipitous drop in the fifth decade. In assessing a group of genomically verified cases of Spitz neoplasms, the drop was much less significant and up to 20% of all Spitz neoplasm cases occurred in patients over 50 years of age.

LIMITATIONS

Limitations included the number of genetically verified Spitz neoplasm cases available and a possible bias as to which cases undergo genomic testing.

CONCLUSION

Genomic verification may allow more confident diagnosis of Spitz neoplasms in patients over 50 years of age and avoid melanoma overdiagnosis.