CXCL5 在心血管疾病、糖尿病和肾脏疾病中的作用机制。
Mechanistic role of CXCL5 in cardiovascular disease, diabetes mellitus, and kidney disease.
机构信息
Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department and Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, Taiwan.
出版信息
Life Sci. 2023 Oct 1;330:122018. doi: 10.1016/j.lfs.2023.122018. Epub 2023 Aug 9.
Chemokines, by modulating inflammation process, could contribute to the development of cardiovascular disease, diabetes mellitus (DM), and kidney disease. Chemokine CXC motif ligand 5 (CXCL5) is one of the inducible chemokines that may be involved in various inflammatory diseases. Given the bidirectional promiscuity characteristics of the chemokine system, the mechanistic roles of CXCL5 should be further explored in each specific disease. In this article, we sought to review the recent evidence on the differential effects of CXCL5 and their potential mechanisms in cardiovascular disease, DM, and renal disease individually. Future study is still required to verify if CXCL5 could be a novel therapeutic target in these diseases.
趋化因子通过调节炎症过程，可能有助于心血管疾病、糖尿病（DM）和肾脏疾病的发展。趋化因子 CXC 基序配体 5（CXCL5）是一种可能参与各种炎症性疾病的诱导性趋化因子。鉴于趋化因子系统的双向混杂特性，CXCL5 的机制作用应在每种特定疾病中进一步探讨。在本文中，我们试图综述 CXCL5 的差异作用及其在心血管疾病、DM 和肾脏疾病中的潜在机制的最新证据。仍需要进一步的研究来验证 CXCL5 是否可以成为这些疾病的新的治疗靶点。
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