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用于研究固体制剂的成像技术:原理与应用。

Imaging techniques for studying solid dosage formulation: Principles and applications.

机构信息

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China..

出版信息

J Control Release. 2023 Sep;361:659-670. doi: 10.1016/j.jconrel.2023.08.013. Epub 2023 Aug 19.

Abstract

Classic methods for evaluating the disintegration and dissolution kinetics of solid dosage forms are no longer sufficient to meet the growing demands in the pharmaceutical field. Hence, scientists have turned to imaging techniques and computer technology to develop innovative visualization methods. These methods allow for a visual understanding of the disintegration or dissolution process and offer valuable insights into the drug release kinetics. This article aims to provide an overview of the commonly used imaging techniques and their applications in studying the disintegration or dissolution of solid dosage forms. Therefore, imaging presents a novel and alternative approach to understanding the mechanisms of disintegration and dissolution in the formulation study of solid dosages.

摘要

经典的方法来评估固体剂型的崩解和溶解动力学已经不再足以满足制药领域日益增长的需求。因此,科学家们转向成像技术和计算机技术,开发创新的可视化方法。这些方法可以直观地了解崩解或溶解过程,并深入了解药物释放动力学。本文旨在概述常用的成像技术及其在研究固体剂型崩解或溶解中的应用。因此,成像为理解固体剂量制剂研究中崩解和溶解机制提供了一种新颖的替代方法。

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