Department of Animal Science, Center for Reproductive Biology and Health, The Pennsylvania State University, AVBS Building, University Park, PA, USA.
Centre de recherche en reproduction et fertilité, Université de Montréal, 3200 rue Sicotte, St-Hyacinthe, QC J2S 7C6, Canada.
Animal. 2023 May;17 Suppl 1:100739. doi: 10.1016/j.animal.2023.100739.
The corpus luteum (CL) is critical for establishment and maintenance of pregnancy in all mammals. However, the fate of the CL in ruminants is dependent on the presence of a functional uterus or signals from a developing embryo to modify uterine function to ensure its own survival. The key molecule secreted by the uterus that must be modified is prostaglandin F2alpha (PGF2A). At the same time, there is evidence that mechanisms within the CL may influence the ability of PGF2A to cause luteolysis. This review focuses on prostaglandins and steroidogenic capacity as endogenous modulators of the sensitivity of the CL to exogenous PGF2A. Early luteal development and early pregnancy are two different luteal stages in which sensitivity of the CL to PGF2A renders it incapable, or less capable, respectively, of undergoing luteolysis in response to PGF2A compared to a midcycle CL. An analysis of molecular changes that occur during these two stages provides some novel insight into molecules and pathways worth exploring to explain the regulation of luteolytic capacity in corpora lutea of ruminants.
黄体（CL）对于所有哺乳动物的妊娠建立和维持至关重要。然而，反刍动物 CL 的命运取决于功能性子宫的存在或来自发育中的胚胎的信号，以改变子宫功能以确保其自身的生存。子宫必须改变的关键分泌分子是前列腺素 F2alpha（PGF2A）。同时，有证据表明，CL 内的机制可能会影响 PGF2A 引起黄体溶解的能力。本综述重点关注前列腺素和甾体生成能力作为 CL 对外源 PGF2A 敏感性的内源性调节剂。早期黄体发育和早期妊娠是黄体的两个不同阶段，与中周期 CL 相比，CL 对 PGF2A 的敏感性使它分别不能或更不能对 PGF2A 作出黄体溶解反应。对这两个阶段发生的分子变化的分析为解释反刍动物黄体中黄体溶解能力的调节提供了一些值得探索的分子和途径的新见解。
