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子宫肌瘤:一个关于患者和医生对医疗管理和新的医疗治疗(Relugolix 联合治疗)观点的播客。

Uterine Fibroids: A Podcast on Patient and Physician Perspectives on Medical Management and a New Medical Therapy (Relugolix Combination Therapy).

机构信息

Fibroid Foundation, Bethesda, MD, USA.

Department of Obstetrics and Gynecology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL, 60637, USA.

出版信息

Adv Ther. 2023 Oct;40(10):4127-4133. doi: 10.1007/s12325-023-02595-x. Epub 2023 Aug 12.

DOI:10.1007/s12325-023-02595-x
PMID:37568061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10499739/
Abstract

Uterine fibroids (UF) are common benign tumors in women and are an important health concern in the US and globally. UF can severely compromise a woman's quality of life, thus making it an important health issue. In this podcast, a professor of Obstetrics and Gynecology, University of Chicago (Dr. Ayman Al-Hendy) and the CEO of the Fibroid Foundation (Sateria Venable) provide their perspectives on the diagnosis and management of UF, including common treatments (e.g., myomectomy or hysterectomy). They also discuss Relugolix combination therapy for UF, noting who could benefit from this treatment and how it works. Podcast audio available for this article.

摘要

子宫肌瘤(UF)是女性常见的良性肿瘤,也是美国和全球的一个重要健康关注点。UF 会严重影响女性的生活质量,因此是一个重要的健康问题。在这个播客中,芝加哥大学妇产科教授(Ayman Al-Hendy 博士)和纤维瘤基金会首席执行官(Sateria Venable)就 UF 的诊断和管理提供了他们的观点,包括常见的治疗方法(如子宫肌瘤切除术或子宫切除术)。他们还讨论了 UF 的 Relugolix 联合疗法,指出谁可能从这种治疗中受益以及它是如何起作用的。本文提供播客音频。

相似文献

1
Uterine Fibroids: A Podcast on Patient and Physician Perspectives on Medical Management and a New Medical Therapy (Relugolix Combination Therapy).子宫肌瘤:一个关于患者和医生对医疗管理和新的医疗治疗(Relugolix 联合治疗)观点的播客。
Adv Ther. 2023 Oct;40(10):4127-4133. doi: 10.1007/s12325-023-02595-x. Epub 2023 Aug 12.
2
Relugolix for the treatment of uterine fibroids.瑞戈非尼用于治疗子宫肌瘤。
Expert Opin Pharmacother. 2020 Oct;21(14):1667-1674. doi: 10.1080/14656566.2020.1787988. Epub 2020 Jul 17.
3
Relugolix combination therapy in Black/African American women with symptomatic uterine fibroids: LIBERTY Long-Term Extension study.雷洛昔芬联合治疗有症状的子宫肌瘤的黑人/非裔美国女性:LIBERTY 长期扩展研究。
Am J Obstet Gynecol. 2024 Feb;230(2):237.e1-237.e11. doi: 10.1016/j.ajog.2023.10.030. Epub 2023 Oct 18.
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Quality of life with relugolix combination therapy for uterine fibroids: LIBERTY randomized trials.用于子宫肌瘤的relugolix联合疗法的生活质量:LIBERTY随机试验。
Am J Obstet Gynecol. 2023 Mar;228(3):320.e1-320.e11. doi: 10.1016/j.ajog.2022.11.1278. Epub 2022 Nov 9.
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The management of uterine leiomyomas.子宫平滑肌瘤的管理
J Obstet Gynaecol Can. 2015 Feb;37(2):157-178. doi: 10.1016/S1701-2163(15)30338-8.
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Changes in symptom burden and quality of life among women with uterine fibroids receiving relugolix combination therapy: a plain language summary.接受瑞戈非尼联合治疗的子宫肌瘤女性患者症状负担和生活质量变化:通俗易懂的概述。
J Comp Eff Res. 2024 Aug;13(8):e230194. doi: 10.57264/cer-2023-0194. Epub 2024 Jun 27.
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Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.用瑞戈非尼联合疗法治疗子宫肌瘤症状。
N Engl J Med. 2021 Feb 18;384(7):630-642. doi: 10.1056/NEJMoa2008283.
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Preoperative medical therapy before surgery for uterine fibroids.子宫肌瘤手术前的术前医学治疗。
Cochrane Database Syst Rev. 2017 Nov 15;11(11):CD000547. doi: 10.1002/14651858.CD000547.pub2.
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Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids.瑞戈非尼/雌二醇/醋酸诺孕酯(去氧孕烯):治疗症状性子宫肌瘤的综述。
Drugs. 2022 Oct;82(15):1549-1556. doi: 10.1007/s40265-022-01790-4. Epub 2022 Nov 4.
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A plain language summary of the long-term relugolix combination therapy study for uterine fibroids.子宫纤维瘤的长效瑞戈非尼联合治疗研究的通俗易懂总结。
J Comp Eff Res. 2023 Aug;12(8):e230069. doi: 10.57264/cer-2023-0069. Epub 2023 Jul 21.

本文引用的文献

1
New treatment options for nonsurgical management of uterine fibroids.治疗子宫肌瘤的非手术治疗新选择。
Curr Opin Obstet Gynecol. 2023 Aug 1;35(4):288-293. doi: 10.1097/GCO.0000000000000880. Epub 2023 May 3.
2
Uterine fibroids - Causes, impact, treatment, and lens to the African perspective.子宫肌瘤——病因、影响、治疗以及非洲视角的解读
Front Pharmacol. 2023 Jan 10;13:1045783. doi: 10.3389/fphar.2022.1045783. eCollection 2022.
3
Management of Uterine Fibroids and Its Complications During Pregnancy: A Review of Literature.妊娠期子宫肌瘤及其并发症的管理:文献综述
Cureus. 2022 Nov 4;14(11):e31080. doi: 10.7759/cureus.31080. eCollection 2022 Nov.
4
Global, regional, and national burden of uterine fibroids in the last 30 years: Estimates from the 1990 to 2019 Global Burden of Disease Study.过去30年全球、区域和国家子宫肌瘤负担:1990年至2019年全球疾病负担研究的估计数。
Front Med (Lausanne). 2022 Nov 7;9:1003605. doi: 10.3389/fmed.2022.1003605. eCollection 2022.
5
Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.长期瑞戈非尼联合治疗症状性子宫肌瘤。
Obstet Gynecol. 2022 Dec 1;140(6):920-930. doi: 10.1097/AOG.0000000000004988. Epub 2022 Nov 2.
6
Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids.瑞戈非尼/雌二醇/醋酸诺孕酯(去氧孕烯):治疗症状性子宫肌瘤的综述。
Drugs. 2022 Oct;82(15):1549-1556. doi: 10.1007/s40265-022-01790-4. Epub 2022 Nov 4.
7
What We Know about the Long-Term Risks of Hysterectomy for Benign Indication-A Systematic Review.关于良性指征子宫切除术长期风险的已知情况——一项系统综述
J Clin Med. 2021 Nov 16;10(22):5335. doi: 10.3390/jcm10225335.
8
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.子宫平滑肌瘤症状的管理:ACOG 实践公告,第 228 号。
Obstet Gynecol. 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401.
9
Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.用瑞戈非尼联合疗法治疗子宫肌瘤症状。
N Engl J Med. 2021 Feb 18;384(7):630-642. doi: 10.1056/NEJMoa2008283.
10
Epidemiology and management of uterine fibroids.子宫肌瘤的流行病学和管理。
Int J Gynaecol Obstet. 2020 Apr;149(1):3-9. doi: 10.1002/ijgo.13102. Epub 2020 Feb 17.